Hepatoprotective Activity of Ethanolic and Ethyl Acetate Extract of Ziziphus mauriatiana on Liver Damaged Caused by Paracetamol in Rats

The objective of the present study was to investigate the hepatoprotective activity of alcoholic and ethyl acetate leaves extract of Ziziphus mauriatiana against paracetamol induced hepatotoxicity. The material was dried in shade, they were powdred and extracted with alcohol and ethyl acetate. Preliminary phytochemical tests were done in the presence of phytoconstituents like flavonoids, saponins, phenolic compounds and tannins. The present activity on rats shown alteration in the level of biochemical markers of hepatic damage like ALT, AST, ALP, Bilirubin and Protin were tested in both paracetamol treated and untreated groups. Wistar rats were induced hepatotoxicity by oral administration of paracetamol (640mg/kg) for 10 days. The hepatotoxicity induced rats were used for the studies. Ethyl acetate extract (400mg/kg), ethanol extract (300mg/kg) and standard (Silymarin) reduced the elevated levels of enzyme markers such as AST, ALT, ALP, and total bilirubin and increased in total proteins levels. The histopathological investigations also supported above effect of ethyl acetate and ethanolic extract by indicating the reduction in inflammatory collection and absence of fatty vacuoles in liver sections.