Synergistic Effect of Natural Sweetener on Antidiabetic Potential of Madhujeevan churna

Objective: To study the effect of dried powder of leaves of S rebaudiana on antidiabetic potential of developed Madhujeevan churna by using alloxan treated Wistar rats.

Materials and Methods: Madhujeevan churna was formulated and developed using Aegle marmelos, Curcuma longa, Azadichta indica, Momordica charantia, Gymnema sylvestre, Salacia reticulata, and Emblica officinalis as active ingredients and Stevia rebaudiana as natural sweetener and nutraceuticals. Churna without Stevia (bitter Churna) and Madhujeevan churna with Stevia (sweet Churna) were evaluated for its antidiabetic activity in alloxan induced diabetic rats. Bitter and sweet Churnas were tested for their antidiabetic potential by blood sugar level, average animal weight and applicable biochemical parameters. Glibenclamide was used as a standard.

Results: Both Churnas showed antidiabetic potential in comparison with standard Glibenclamide. Both Churnas were significantly superior to control in reducing blood sugar as well as weight of animals. Madhujeevan Churna containing natural sweetener showed marked reduction in total cholesterol, HDL cholesterol, tiglyceride, SGOT, SGPT, VLDL, creatinine and uric acid as compare to standard and bitter Madhujeevan churna.

Conclusion: Sweet churna showed significant synergistic effect in comparison to Churna without Stevia. Aqueous extract of dried leaves of Stevia rebaudiana acts as a natural antidiabetic agent.