Evaluation of Wound Healing and Anti-Oxidant Property of Seed Oil of Morinda citrifolia L (Noni) in Wistar Rats

Wound healing is a complex pathway that is energy dependent. Nonhealing wounds frequently require the use of physical agents to achieve healing. Wound healing disorders present a serious clinical problem and are likely to increase since they are associated with disease such as diabetes, hypertension and obesity. Additionally, increasing life expectancies will cause more people to face such disorders and further aggravate problem thus several animal models have been established to serve as an experimental basis to determine molecular and cellular mechanisms underlying and controlling an undisturbed healing process. Morinda citrifolia L. (Noni) (Rubiaceae) has been used in folk remedies by Polynesians, Indians for over 2000 years, and is reported to have a broad range of therapeutic effects, including antibacterial, antiviral, antifungal, antitumor, antihelmintic, analgesic, hypotensive, anti-inflammatory, and immune enhancing effects.

This paper describes a common biochemical pathway that helps to understand, at a molecular level, how the transfer of energy to a wound can result in positive results. The mechanism of action for seed oil of Morinda citrifolia L (Noni) is reviewed along with biochemical estimations. Based on our study we conclude that test compound is showing potent anti-oxidant and wound healing activity when compared with positive control i.e. Allanzyme and the biochemical estimations also favoured to us in this case.