Research Journal of Pharmacognosy and Phytochemistry

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Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats


Affiliations
1 Aspm’s K. T. Patil College o Pharmacy, Post Box No.-56, Siddharth Colony, Siddharth Nagar, Osmanabad 413501(M.S.), India
2 ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, India
     

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The different extracts of the Marsilea quadrifolia linn (Family- Marsileaceae) were tested for anti-diabetic activity, by normal rats and alloxan induced diabetic rats. Aqueous and methanol extracts had shown significant protection and lowered the blood glucose level. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 72h at a dose level of 200mg/kg body weight. In short term treatment of alloxan induced diabetic rats was determined by measuring blood glucose levels on 0,24,48 and 72h. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide. These results indicate that the Marsilea quadrifolia linn plant possess significant anti-diabetic activity.

Keywords

Antidiabetic Activity, Marsilea quadrifolia, Glucose, Glibenclamide.
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  • Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats

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Authors

Shirish Satish Dongare
Aspm’s K. T. Patil College o Pharmacy, Post Box No.-56, Siddharth Colony, Siddharth Nagar, Osmanabad 413501(M.S.), India
A. P. Maske
ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, India
S. M. Patil
ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, India
R. P. Umbare
ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, India
G. S. Mate
ASPM’s K. T. Patil. College of Pharmacy, Osmanabad, India

Abstract


The different extracts of the Marsilea quadrifolia linn (Family- Marsileaceae) were tested for anti-diabetic activity, by normal rats and alloxan induced diabetic rats. Aqueous and methanol extracts had shown significant protection and lowered the blood glucose level. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 72h at a dose level of 200mg/kg body weight. In short term treatment of alloxan induced diabetic rats was determined by measuring blood glucose levels on 0,24,48 and 72h. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide. These results indicate that the Marsilea quadrifolia linn plant possess significant anti-diabetic activity.

Keywords


Antidiabetic Activity, Marsilea quadrifolia, Glucose, Glibenclamide.