Research Journal of Pharmacognosy and Phytochemistry

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Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats


Affiliations
1 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
2 Department of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
3 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
4 Department of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
     

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Objective: The present study is designed to investigate anti-inflammatory activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae).

Methods: Acute inflammation models like histamine-induced and eggalbumin- induced rat paw edema model and xylene induced ear oedema in mice were employed to investigate the anti-inflammatory activity. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), lipid per oxidation and alkaline phosphatase (ALP) were also estimated as supportive study.

Results: The extract at doses 150mg/kg b.w. and 300mg/kg b.w. and diclofenac sodium (standard) showed significant anti-inflammatory in all the models, as compared to control (p< 0.0001). The extract and standard drug also showed significant (p<0.0001) results for biochemical parameters.

Conclusion: The results of the present further confirm the use of Borassus flabellifer L. traditionally for the treatment of painful inflammatory conditions.


Keywords

Borassus flabellifer L., Inflorescences, Male Flowers, Antiinflammatory, Histamine, Egg-Albumin, SGOT, SGPT, Lipid Per Oxidation, ALP.
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  • Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats

Abstract Views: 239  |  PDF Views: 0

Authors

Sachin R. Patil
Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
M. B. Patil
Department of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
Ravi Kumar
Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India
Mahesh S. Paschapur
Department of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India

Abstract


Objective: The present study is designed to investigate anti-inflammatory activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae).

Methods: Acute inflammation models like histamine-induced and eggalbumin- induced rat paw edema model and xylene induced ear oedema in mice were employed to investigate the anti-inflammatory activity. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), lipid per oxidation and alkaline phosphatase (ALP) were also estimated as supportive study.

Results: The extract at doses 150mg/kg b.w. and 300mg/kg b.w. and diclofenac sodium (standard) showed significant anti-inflammatory in all the models, as compared to control (p< 0.0001). The extract and standard drug also showed significant (p<0.0001) results for biochemical parameters.

Conclusion: The results of the present further confirm the use of Borassus flabellifer L. traditionally for the treatment of painful inflammatory conditions.


Keywords


Borassus flabellifer L., Inflorescences, Male Flowers, Antiinflammatory, Histamine, Egg-Albumin, SGOT, SGPT, Lipid Per Oxidation, ALP.