Research Journal of Pharmacognosy and Phytochemistry

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Application of Seed Polymer Extracted from Benincasa hispida for Development of Fast Dissolving Tablet of Carvedilol


Affiliations
1 Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India
2 Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India
3 Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India
     

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Natural polymers are preferred over synthetic polymers as they are nontoxic, facilely available at low cost, utilized in low concentration, and are naturally extracted to provide nutritional supplement. Fast dissolving tablets have received ever-increasing demand during the last decade. Aim of present study was to develop fast dissolving tablet of Carvedilol using seed polymer extracted from Benincasa hispida. Prepared tablets were evaluated for pre and post compression parameters. Results of compatibility study using FTIR and DSC showed that Carvedilol is compatible with extracted seed polymer. Pre-compression studies revealed good micromeritic properties of powder blend for direct compression. In-vitro dissolution study showed that, tablet containing seed polymer released 90.67% of drug within 60 min. Study concluded that, natural superdisintegrant extracted from Benincasa hispida can be efficaciously utilized in tablet formulations which exhibit faster drug dissolution and hence may increase bioavailability, thereby, availing in efficacious therapy with improved patient compliance.

Keywords

Benincasa hispida, Seed Polymer, Natural Superdisintegrant, Fast Dissolving Tablet, Carvedilol.
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  • Application of Seed Polymer Extracted from Benincasa hispida for Development of Fast Dissolving Tablet of Carvedilol

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Authors

Suresh G. Killedar
Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India
Durgacharan A. Bhagwat
Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India
Sneha S. Jadhav
Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India

Abstract


Natural polymers are preferred over synthetic polymers as they are nontoxic, facilely available at low cost, utilized in low concentration, and are naturally extracted to provide nutritional supplement. Fast dissolving tablets have received ever-increasing demand during the last decade. Aim of present study was to develop fast dissolving tablet of Carvedilol using seed polymer extracted from Benincasa hispida. Prepared tablets were evaluated for pre and post compression parameters. Results of compatibility study using FTIR and DSC showed that Carvedilol is compatible with extracted seed polymer. Pre-compression studies revealed good micromeritic properties of powder blend for direct compression. In-vitro dissolution study showed that, tablet containing seed polymer released 90.67% of drug within 60 min. Study concluded that, natural superdisintegrant extracted from Benincasa hispida can be efficaciously utilized in tablet formulations which exhibit faster drug dissolution and hence may increase bioavailability, thereby, availing in efficacious therapy with improved patient compliance.

Keywords


Benincasa hispida, Seed Polymer, Natural Superdisintegrant, Fast Dissolving Tablet, Carvedilol.

References