Research Journal of Pharmacognosy and Phytochemistry

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Ethnopharmacological Story of Guggul Sterones:An Overview


Affiliations
1 Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhan Sabha, Raipur -493111 Dist-Raipur (C.G.), India
2 University Department of Pharmaceutical Sciences, Utkal University, Vanivihar, Bhubaneswar, Odisha-751004, India
3 School of Pharmaceutical Education and Research, Berhampur University, Odisha-760007, India
     

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Medicinal plants have played an important role throughout the world in treating and preventing human diseases, commiphora wightii is an important medicinal plant of herbal heritage of India. Guggul is obtained from commiphora mukul which belong to the Family, Burseraceae . C. mukul occurs in north east Africa, Somali and southern Arabia , in India it is found in Gujrat, Mysore , Bengal, M. Pradesh , Desert of Rajastasthan a list of few Commiphora species C. Mukul, C. Myrrh , C. Stocksiana Engl, C. Caudate Engl. etc, Guggul tree is small ,1.2-1.8 m high. Each plant yield about one kilogram of the product which is collected in cold Season, isolation of guggul sterons , extract with EtOAC yield soluble fraction and insoluble fraction, soluble fraction consist of 45% gum resin while 55% insoluble fraction contains carbohydrate, there is no any therapeutic property reported. Guggul lipid has active ingredients like Ketosteroids cis and trans is also known as sterones. guggulsterone-I, II, III, IV, V, VI, myrcene, dimyrcene, bioactive compounds in extract of mukul reported are dimyrcene, 15 α- camphorene. 16 linoleic, oleic, stearic, palmitic acid, sitosterol etc. It is therapeutically used in obesity hyperlipidaemia, arthritis, coronary thrombosis, cardiac disorders, diabetes, tumours, thyroid disorders, hepatic obstructions and weakness pharyngitis etc. Marketed formulation of Guggul triphala Guggul, Yougaraja Guggul, kaishora gugguln, Navaka guggul etc.

Keywords

Commiphora Mukul, Chemistry, Guggul Lipid, Therapeutic Uses.
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  • Ethnopharmacological Story of Guggul Sterones:An Overview

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Authors

Suresh Kumar Ghritlahare
Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhan Sabha, Raipur -493111 Dist-Raipur (C.G.), India
Trilochan Satapathy
Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhan Sabha, Raipur -493111 Dist-Raipur (C.G.), India
Prasanna Kumar Panda
University Department of Pharmaceutical Sciences, Utkal University, Vanivihar, Bhubaneswar, Odisha-751004, India
Geetanjali Mishra
School of Pharmaceutical Education and Research, Berhampur University, Odisha-760007, India

Abstract


Medicinal plants have played an important role throughout the world in treating and preventing human diseases, commiphora wightii is an important medicinal plant of herbal heritage of India. Guggul is obtained from commiphora mukul which belong to the Family, Burseraceae . C. mukul occurs in north east Africa, Somali and southern Arabia , in India it is found in Gujrat, Mysore , Bengal, M. Pradesh , Desert of Rajastasthan a list of few Commiphora species C. Mukul, C. Myrrh , C. Stocksiana Engl, C. Caudate Engl. etc, Guggul tree is small ,1.2-1.8 m high. Each plant yield about one kilogram of the product which is collected in cold Season, isolation of guggul sterons , extract with EtOAC yield soluble fraction and insoluble fraction, soluble fraction consist of 45% gum resin while 55% insoluble fraction contains carbohydrate, there is no any therapeutic property reported. Guggul lipid has active ingredients like Ketosteroids cis and trans is also known as sterones. guggulsterone-I, II, III, IV, V, VI, myrcene, dimyrcene, bioactive compounds in extract of mukul reported are dimyrcene, 15 α- camphorene. 16 linoleic, oleic, stearic, palmitic acid, sitosterol etc. It is therapeutically used in obesity hyperlipidaemia, arthritis, coronary thrombosis, cardiac disorders, diabetes, tumours, thyroid disorders, hepatic obstructions and weakness pharyngitis etc. Marketed formulation of Guggul triphala Guggul, Yougaraja Guggul, kaishora gugguln, Navaka guggul etc.

Keywords


Commiphora Mukul, Chemistry, Guggul Lipid, Therapeutic Uses.

References