Research Journal of Pharmacognosy and Phytochemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Review on Urolithiasis and its Treatment using Plants


Affiliations
1 Shree Krishna Institute of Pharmacy, Bechraji, Gujarat, India
2 Claris Life Sciences Ltd., Ahmedabad, Gujarat, India
3 Rofel College of Pharmacy, Vapi, Gujarat, India
     

   Subscribe/Renew Journal


A kidney stone, also known as a renal calculus (from the Latin ren, "kidney" and calculus, "pebble") is a solid concretion or crystal aggregation formed in the kidneys from dietary minerals in the urine. Stone formation in the kidney is one of the oldest and most wide spread diseases known to man. Urinary stone disease has afflicted humankind since antiquity and can persist, with serious medical consequences, throughout a patient’s lifetime. In addition, the incidence of kidney stones has been increased in western societies in the last five decades, in association with economic development. Most calculi in the urinary system arise from a common component of urine, e.g. calcium oxalate (CaOx), representing up to 80% of analyzed stones. The problem of urinary stones or calculi is a very ancient one and many remedies have been employed during the ages these stones are found in all parts of the urinary tract, the kidney, the ureters and the urinary bladder and may vary considerably in size. The present day medical management of lithiasis includes lithotripsy and surgical procedures. Unfortunately, these techniques do not correct the underlying risk factors. Also, the overuse of synthetic drugs, which results in higher incidence of adverse drug reactions, has motivated humans to return to nature for safe remedies. Many plants conveniently available in India are used in traditional folklore medicine for the treatment of lithiasis (kidney stone. Herbs and herbal drugs have created interest among the people by its clinically proven effects like immunomodulation, adaptogenic and antimutagenic. In the present article, an attempt has been made to emphasis on herbal option for urinary stone.

Keywords

Lithiasis, Ureters, Urinary Stones, Adaptogenic, Antimutageni.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Mohammed Touhami,Amine Laroubi, Khadija Elhabazi, Farouk Loubna, Ibtissam Zrara, younes Eljahiri et al. Lemon juice has protective activity in a rat urolithiasis model. BMC Urol 2007; 7: 18.

  • Moe, O.W., 2006. Kidney stones: pathophysiology and medical management. Lancet 367, 333–344.

  • Tiselius, H.G., 2003. Epidemiology and medical management of stone disease. BJU International 91, 758–767.

  • Baumann, J.M., 1998. Stone prevention: why so little progress? Urological Research 26, 77–81.

  • Tiselius, H.G., Hallin, A., Lindbäck, B., 2001. Crystallization properties in stone forming and normal subject’s urine diluted using a standardized procedure to match the composition of urine in the distal part of the distal tubule and the middle part of the collecting duct. Urological Research 29, 75–82.

  • A http://www.kidney.niddk.nih.gov/ (13/09/2005)

  • Christina, AJ, Priya ,Mole, M, and Moorthy, P.,(2002), Studies on the antilithic effect of Rotula aquatica lour in male wistar rats. Methods find Exp clin pharmacol, 24(6), 357-9.

  • Christiana ,W., Barbara,W.,Wirleinter, k., (2005) , Extracts of pumpkin (cucurbita pepo L.) seeds suppress stimulated peripheral Blood Monouclear cells in vitro .American Journal of Immunology, 1 (1) : 6-11

  • Hodgkinson, and Williams, Ann., (1972), An improved colorimetric procedure for urine oxalate. Clinica Chimica Acta, 36, 127-132.

  • Kishimoto T, Yamamoto K, Sugimoto T, Yoshihara H, Maekawa M. Side effects of extracorporeal shock-wave exposure in patients treated by extracorporeal shock-wave lithotripsy for upper urinary tract stone. European Urology 1986; 12:308– 313.

  • Begun FP, Knoll CE, Gottlieb M, Lawson RK. Chronic effects of focused electrohydraulic shock-waves on renal function and hypertension. The Journal of Urology1991; 145:635–639.

  • Pak, C.Y.C., 1989. Role of medical prevention. Journal of Urology 141, 798–801.

  • Hess, B., 2003. Pathophysiology, diagnosis and conservative therapy in calcium kidney calculi. Therapeutische Umschau. Revue thérapeutique 60, 79–87.

  • Kraisintu, K., 2003. The status of medicinal and aromatic plants in Cambodia, Laos, the Philippines, Thailand and Vietnam. In: Vasisht, K., Kumar, V. (Eds.), Medicinal Plants and Their Utilization. United Nations Industrial Development Organization and the International Centre for Science and High Technology, Trieste, pp.3–54.

  • Atmani, F., Slimani, Y., Mimouni, M., Hacht, B., 2003. Prophylaxis of calcium oxalate stone by Herniaria hirsute on experimentally induced nephrolithiasis in rats. BJU International 92, 137–140.

  • Barros, M.E., Lima, R., Mercuri, L.P., Matos, J.R., Schor, N., Boim, M.A., 2006. Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis. Urological Research 34, 351–357. 17. Reilly Jr. RF, Chapter 13: Nephrolithiasis, pp. 192–207 in Reilly Jr. and Perazella (2005)

  • Coe, FL; Evan, A; Worcester, E (2005). "Kidney stone disease". The Journal of Clinical Investigation 115 (10): 2598–608.

  • Hoppe, B; Langman, CB (2003). "A United States survey on diagnosis, treatment, and outcome of primary hyperoxaluria". Pediatric Nephrology 18 (10): 986–91.

  • National Endocrine and Metabolic Diseases Information Service (2006). "Hyperparathyroidism (NIH Publication No. 6–3425)". Information about Endocrine and Metabolic Diseases: A-Z list of Topics and Titles. Bethesda, Maryland: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Public Health Service, US Department of Health and Human Services. Retrieved 2011-07-27.

  • National Endocrine and Metabolic Diseases Information Service (2008). "Renal Tubular Acidosis (NIH Publication No. 09– 4696)". Kidney & Urologic Diseases: A-Z list of Topics and Titles. Bethesda, Maryland: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Public Health Service, US Department of Health and Human Services. Retrieved 2011-07-27.

  • Weiss, M; Liapis, H; Tomaszewski, JE; Arend, LJ (2007). "Chapter 22: Pyelonephritis and other infections, reflux nephropathy, hydronephrosis, and nephrolithiasis". In Jennette, JC; Olson, JL; Schwartz, MM et al.. Heptinstall's Pathology of the Kidney. 2 (6th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 991–1082.

  • Moe, OW (2006). "Kidney stones: pathophysiology and medical management". The Lancet 367 (9507): 333–44.

  • Johri, N; Cooper B, Robertson W, Choong S, Rickards D, Unwin R (2010). "An update and practical guide to renal stone management". Nephron Clinical Practice 116 (3): c159–71.

  • Halabe, A; Sperling, O (1994). "Uric acid nephrolithiasis". Mineral and Electrolyte Metabolism 20 (6): 424–31.

  • Kamatani, N (1996). "Adenine phosphoribosyltransferase (APRT) deficiency" (in Japanese). Nippon Rinsho. Japanese Journal of Clinical Medicine 54 (12): 3321–7.

  • Rosenberg, LE; Durant JL, Elsas LJ (1968). "Familial iminoglycinuria. An inborn error of renal tubular transport". The New England Journal of Medicine 278 (26): 1407–13.

  • Coskun T, Ozalp I, Tokatli A (1993). "Iminoglycinuria: a benign type of inherited aminoaciduria". The Turkish Journal of Pediatrics 35 (2): 121–5.

  • Merck Sharp & Dohme Corporation (2010). "Patient Information about Crixivan for HIV (Human Immunodeficiency Virus) Infection". Crixivan® (indinavir sulfate) Capsules. Whitehouse Station, New Jersey: Merck Sharp & Dohme Corporation. Retrieved 2011-07-27.

  • Schlossberg, D; Samuel, R (2011). "Sulfadiazine". Antibiotic Manual: A Guide to Commonly Used Antimicrobials (1st ed.). Shelton, Connecticut: People's Medical Publishing House. pp. 411–12.

  • Carr, MC; Prien EL Jr, Babayan RK (1990). "Triamterene nephrolithiasis: renewed attention is warranted". Journal of Urology 144 (6): 1339–40.

  • McNutt, WF (1893). "Chapter VII: Vesical Calculi (Cystolithiasis)". Diseases of the kidneys and bladder: a text-book for students of medicine. IV: Diseases of the Bladder. Philadelphia: J.B. Lippincott Company. pp. 185–6.

  • Preminger, GM (2007). "Chapter 148: Stones in the Urinary Tract". In Cutler, RE. The Merck Manual of Medical Information Home Edition (3rd ed.). Whitehouse Station, New Jersey: Merck Sharp and Dohme Corporation.

  • Wolf Jr. JS (2011). "Background". Nephrolithiasis. New York: WebMD. Retrieved 2011-07-27.

  • Pearle, MS; Calhoun, EA; Curhan, GC (2007). "Chapter 8: Urolithiasis". In Litwin, MS; Saigal, CS. Urologic Diseases in America (NIH Publication No. 07–5512). Bethesda, Maryland: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, United States Public Health Service, United States Department of Health and Human Services. pp. 283–319.

  • Cavendish, M (2008). "Kidney disorders". Diseases and Disorders. 2 (1st ed.). Tarrytown, New York: Marshall Cavendish Corporation. pp. 490–3.

  • The Useful Plant of India, Publications & Information Directorate (CSIR New Delhi), 1986:86.

  • http://kidney.niddk.nih.gov/kudiseases/pubs/stone sadults.


Abstract Views: 1012

PDF Views: 0




  • A Review on Urolithiasis and its Treatment using Plants

Abstract Views: 1012  |  PDF Views: 0

Authors

Vrunda Zalavadiya
Shree Krishna Institute of Pharmacy, Bechraji, Gujarat, India
Vipul Shah
Claris Life Sciences Ltd., Ahmedabad, Gujarat, India
D.D. Santani
Rofel College of Pharmacy, Vapi, Gujarat, India

Abstract


A kidney stone, also known as a renal calculus (from the Latin ren, "kidney" and calculus, "pebble") is a solid concretion or crystal aggregation formed in the kidneys from dietary minerals in the urine. Stone formation in the kidney is one of the oldest and most wide spread diseases known to man. Urinary stone disease has afflicted humankind since antiquity and can persist, with serious medical consequences, throughout a patient’s lifetime. In addition, the incidence of kidney stones has been increased in western societies in the last five decades, in association with economic development. Most calculi in the urinary system arise from a common component of urine, e.g. calcium oxalate (CaOx), representing up to 80% of analyzed stones. The problem of urinary stones or calculi is a very ancient one and many remedies have been employed during the ages these stones are found in all parts of the urinary tract, the kidney, the ureters and the urinary bladder and may vary considerably in size. The present day medical management of lithiasis includes lithotripsy and surgical procedures. Unfortunately, these techniques do not correct the underlying risk factors. Also, the overuse of synthetic drugs, which results in higher incidence of adverse drug reactions, has motivated humans to return to nature for safe remedies. Many plants conveniently available in India are used in traditional folklore medicine for the treatment of lithiasis (kidney stone. Herbs and herbal drugs have created interest among the people by its clinically proven effects like immunomodulation, adaptogenic and antimutagenic. In the present article, an attempt has been made to emphasis on herbal option for urinary stone.

Keywords


Lithiasis, Ureters, Urinary Stones, Adaptogenic, Antimutageni.

References