Research Journal of Pharmacognosy and Phytochemistry

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Comparative Evaluation of Anthelmintic Potential of Cucurbita maxima Seeds, Moringa oleifera Seeds and Solanum surattense Fruits


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1 Maharajah's College of Pharmacy, Phoolbaugh, Vizianagaram, Andhra Pradesh, India
     

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The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause severe morbidities including lymphatic filariasis and onchocerciasis. Development of resistance to most of the commercially available anti helminthiasis becomes a severe problem worldwide. The present study was under taken to evaluate antihelmenthic activity of ethanol extract of seeds of Cucurbita maxima, Moringa olifera and fruits of Solanum surattense on Indian earthworm pheritima phosthuma. Various concentrations (10, 25, 50 mg/ml) of extracts were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10 mg/ml) is used as reference standard and saline water as control.

Keywords

Antihelmenthic Activity, Pheritima Posthuma, Cucurbita maxima, Moringa olifera, Solanum surattense.
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  • Hammond JA, Fielding D, Bishop SC. Prospects for plant anthelmintics in tropical veterinary medicine. Veterinary Research Communications. 21(3); 1997: 213-28.

  • Fajami AK, Taiwo AA. Herbal remidies in animal parasitic diseases in Nigeria: A review. African Journal of Biotechnology. 4; 2005:303-7.

  • Gathuma JM, Mbaria JM, Wanyama J, Kaburia HF, Mpoke L, Mwangi JN. Effect of myrsine Africana, Albizia anthelmintica and Hilderbrantia sepalosa herbal remedies in samburu district, Kenya. Journal of Ethnopharmcology. 91; 2004:7-12.

  • Shailendra W, Mangal SP, Navdeep S, Swati R, Sarita S. A review on commercial, traditional uses phytoconstituents and pharmacological activity of Moringa oleifera. Global journal of traditional medicinal systems. 2(1); 2013:1-13.

  • Patel S, Thakur AS, Chanday A, Manigauha A. Moringa oleifera: A Review of their medicinal and economical importance to the health and nation. Drug invention today. 2(7); 2010: 339-342.

  • Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: A food plant with multiple medicinal uses. Phytotherapy Research. 21 (1); 2007:17-25.

  • Berger MR., Habs M, Jahn SA, Schmahl D, Toxicological assessment of seeds from Moringa oleifera and Moringa stenopetala, two highly efficient primary coagulants for domestic water treatment of tropical raw waters. East African Medical Journal.61; 1984: 712-716.

  • Nadkarni KM. Indian Materia Medica. Popular Prakashan, Mumbai. 1996.

  • Pal SK, Mukherjee PK, Saha BP. Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats. Phytotherapy Research. 9(6); 1995: 463-465.

  • Agrawal B, Mehta A. Antiasthmatic activity of Moringa oleifera Lam: A clinical study. Indian Journal of Pharmacology. 40 (1); 2008:28-31.

  • Sharma R, Vaghela JS. In vivo antioxidant activity of Moringa oleifera leaf and pod extracts against carbon tetra chloride induced liver damage in albino mice. Journal of Chemical and Pharmaceutical Research. 2(6); 2010: 275-283.

  • Rastogi T, Bhutda V, Moon K, Aswar PB, Khadabad SS. Comparative studies on anthelmintic activity of Moringa oleifera and Vitex Negundo. Asian Journal of Research in Chemistry. 2(2); 2009: 181-182.

  • Anwar F, Rashid U. Physico-chemical characteristics of Moringa oleifera seeds and seed oil from a wild Provenance of Pakistan. Pakistan Journal of Botany. 39(5); 2007: 1443-1453.

  • Prajapti NS, Purohit SS, Sharma AK, and Kumar T. A Handbook of Medicinal Plants. Agrobios (India), Jodhpur. 2006.

  • Kirtikar KR and Basu BD. Indian Medicinal Plants. Oriental Enterprises, Uttaranchal, India. 2003.

  • Yadav M, Jain S, Tomar R, Prasad GB and Yadav H. Medicinal and biological potential of pumpkin: an updated review. Nutrition Research Review. 23(2); 2010:184-90.

  • Ravishankar K et al. Preliminary phytochemical screening and invitro antibacterial activity of Cucurbita maxima seed extract. International Journal of Research in Pharmacy and Chemistry. 2(1); 2012: 86-91.

  • Siddiqui S, Faizi S, Shaheen B. Studies in the chemical constituents of the fresh berries of Solanum xanthocarpum Schrad. and Wendle. Journal of Chemical Society of Pakistan. 5; 1983: 99-102.

  • Nadkarni KM. Indian Materia Medica. Popular Publication, Mumbai. 2009.

  • Roshy JC, Ilanchezhian R, Patgiri BJ. Therapeutic potentials of kantakari (Solanum xanthocarpum schrad. and wendl.). Ayurpharm - International Journal of Ayurveda and Allied Sciences. 1(2); 2012: 46-53.

  • Ghosh T, Maity TK, Bose A, Dash GK. Anthelmintic activity of Bacopa monierri. Indian Journal of Natural Product. 21; 2005: 16-19.

  • Vidyarthi RD. A text book of Zoology. Chand and Co., New Delhi. 1967.

  • Thorn GW, Adams RD, Braunwald E, Isselbacher KJ and Petersdrop RG. Harrisons Principles of internal Medicine. Megraw Hill Co., New York. 1977.

  • Vigar Z. Atlas of Medical Parasitology. P.G Publishing House, Singapore. 1984.

  • Chatterjee KD. Parasitology, Protozoology and Helminthology. In Guha Ray Sree Saraswaty Press Ltd, Calcutta.1967.


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  • Comparative Evaluation of Anthelmintic Potential of Cucurbita maxima Seeds, Moringa oleifera Seeds and Solanum surattense Fruits

Abstract Views: 403  |  PDF Views: 2

Authors

Saroj Kumar Raul
Maharajah's College of Pharmacy, Phoolbaugh, Vizianagaram, Andhra Pradesh, India
Gopal Krishna Padhy
Maharajah's College of Pharmacy, Phoolbaugh, Vizianagaram, Andhra Pradesh, India
Soudamini Alekha Charan
Maharajah's College of Pharmacy, Phoolbaugh, Vizianagaram, Andhra Pradesh, India
Neelima Gurubarik
Maharajah's College of Pharmacy, Phoolbaugh, Vizianagaram, Andhra Pradesh, India

Abstract


The medicinal plants are widely used by the traditional medical practitioners for curing various diseases. Helminthiasis is the most common infection in human affecting a large proportion of world population. Parasitic diseases may cause severe morbidities including lymphatic filariasis and onchocerciasis. Development of resistance to most of the commercially available anti helminthiasis becomes a severe problem worldwide. The present study was under taken to evaluate antihelmenthic activity of ethanol extract of seeds of Cucurbita maxima, Moringa olifera and fruits of Solanum surattense on Indian earthworm pheritima phosthuma. Various concentrations (10, 25, 50 mg/ml) of extracts were tested and results were expressed in terms of time of paralysis and time of death of the worm. Piperazine citrate (10 mg/ml) is used as reference standard and saline water as control.

Keywords


Antihelmenthic Activity, Pheritima Posthuma, Cucurbita maxima, Moringa olifera, Solanum surattense.

References