Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Antidiarrhoeal Activity Cleome gynandra Leaf Extracts on Magnesium Sulphate- and Castor Oil-Induced Diarrhoea in Wistar Rats


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1 Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
     

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The methanolic extract leaves of Cleome gynandra (Family Capparidaceae) was selected to evaluate the antidiarrhoeal activity against castor oil and magnesium sulphate induced diarrhoea in wistar albino rats. The present study was performed at three different doses of 100 mg/kg, 200mg/kg and 400mg/kg methanolic extract of plant. The Methanolic plant extracts shows more effective antidiarrhoeal activity against castor-oil induced diarrhea compared to magnesium sulphate induced diarrhoea in a dose dependent manner. From the results we conclude that methanolic leaf extracts of Cleome gynandra had reported antidiarrhoeal activity similar to standard drug loperamaide at dose of 3 mg/kg.

Keywords

Cleome gynandra, Antidiarrhoeal Activity, Loperamide, Castor Oil, Magnesium Sulphate.
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  • Evaluation of Antidiarrhoeal Activity Cleome gynandra Leaf Extracts on Magnesium Sulphate- and Castor Oil-Induced Diarrhoea in Wistar Rats

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Authors

Nadiminti Satish Reddy
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
D. Santhosha
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
Vidyasabbani
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
P. Vishwanath Reddy
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India
Venu
Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

Abstract


The methanolic extract leaves of Cleome gynandra (Family Capparidaceae) was selected to evaluate the antidiarrhoeal activity against castor oil and magnesium sulphate induced diarrhoea in wistar albino rats. The present study was performed at three different doses of 100 mg/kg, 200mg/kg and 400mg/kg methanolic extract of plant. The Methanolic plant extracts shows more effective antidiarrhoeal activity against castor-oil induced diarrhea compared to magnesium sulphate induced diarrhoea in a dose dependent manner. From the results we conclude that methanolic leaf extracts of Cleome gynandra had reported antidiarrhoeal activity similar to standard drug loperamaide at dose of 3 mg/kg.

Keywords


Cleome gynandra, Antidiarrhoeal Activity, Loperamide, Castor Oil, Magnesium Sulphate.