Research Journal of Pharmacology and Pharmacodynamics

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Hepatoprotective Activity of Stem Bark of Nyctanthes arbor-Tristis linn


Affiliations
1 Columbia College of Pharmacy, Raipur-493111, C.G., India
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur 492010, C.G., India
3 TIT College of Pharmacy, Bhopal-462001, M.P., India
     

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The present study is to evaluate the hepatoprotective effects of the 50% hydro-ethanol (Heena) extracts of stem bark of Nyctanthes arbor-tristis linn, against paracetamol induced hepatotoxicity in rats. The hepatoprotective effects of HEENA (500 mg/kg) was estimated by liver function test and serum profile. The results revealed that the extract of selected plant produce significant hepatoprotective effect not only by decreasing serum transaminase (SGPT and SGOT), alkaline phosphate and total bilirubin, but also significantly increased the levels of serum proteins (albumin, fibrinogen haeptoglobin, ceruloplasin, transferring etc). The effects of Heena was comparable with standard drug silymarin.

Keywords

Hepatotoxicity, Nyctanthes arbor-Tristis linn, Heena, SGPT, SGOT.
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  • Hepatoprotective Activity of Stem Bark of Nyctanthes arbor-Tristis linn

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Authors

Vaibhav Tripathi
Columbia College of Pharmacy, Raipur-493111, C.G., India
Adeep Kujur
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur 492010, C.G., India
Manmeet Singh Saluja
TIT College of Pharmacy, Bhopal-462001, M.P., India

Abstract


The present study is to evaluate the hepatoprotective effects of the 50% hydro-ethanol (Heena) extracts of stem bark of Nyctanthes arbor-tristis linn, against paracetamol induced hepatotoxicity in rats. The hepatoprotective effects of HEENA (500 mg/kg) was estimated by liver function test and serum profile. The results revealed that the extract of selected plant produce significant hepatoprotective effect not only by decreasing serum transaminase (SGPT and SGOT), alkaline phosphate and total bilirubin, but also significantly increased the levels of serum proteins (albumin, fibrinogen haeptoglobin, ceruloplasin, transferring etc). The effects of Heena was comparable with standard drug silymarin.

Keywords


Hepatotoxicity, Nyctanthes arbor-Tristis linn, Heena, SGPT, SGOT.