Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Anti-Diabetic and Anti-Inflammatory Activities of Ethanolic Extract of whole Plant of Inula racemosa


Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, India
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, India
     

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The present study was designed to evaluate the antidiabetic and anti-inflammatory activity of ethanolic extract of whole plant of "Inula racemosa" using different animal models. Antidiabetic activity was evaluated by using various two animal models. The alloxan induced diabetes method and streptozocin induced diabetes method along with biochemical parameters like SALP, SGPT, SGOT, Triglycerides, Total proteins were employed to investigate antidiabetic potential of Inula racemosa. Anti-inflammatory activity was evaluated using formalin induced paw edema model and croton oil ear edema model. Carrageenan induced paw edema model uses change in paw volume of control, test, and standard respectively to find out percentage inhibition of edema. The study revealed that the whole plant of "Inula racemosa" possess a significant anti-diabetic and anti-inflammatory activity.

Keywords

Inula racemosa, Alloxan Induced Diabetes Method, Streptozocin Induced Diabetes Method, Formalin Induced Paw Edema Model, Croton Oil Ear Edema Model.
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  • Evaluation of Anti-Diabetic and Anti-Inflammatory Activities of Ethanolic Extract of whole Plant of Inula racemosa

Abstract Views: 321  |  PDF Views: 2

Authors

Sanu G. Sam
Department of Pharmacology, Karavali College of Pharmacy, Mangalore, India
Anjan Kumar
Department of Pharmacology, Karavali College of Pharmacy, Mangalore, India
D. Veeresh Babu
Department of Pharmacology, Karavali College of Pharmacy, Mangalore, India
V. B. Narayana Swamy
Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, India

Abstract


The present study was designed to evaluate the antidiabetic and anti-inflammatory activity of ethanolic extract of whole plant of "Inula racemosa" using different animal models. Antidiabetic activity was evaluated by using various two animal models. The alloxan induced diabetes method and streptozocin induced diabetes method along with biochemical parameters like SALP, SGPT, SGOT, Triglycerides, Total proteins were employed to investigate antidiabetic potential of Inula racemosa. Anti-inflammatory activity was evaluated using formalin induced paw edema model and croton oil ear edema model. Carrageenan induced paw edema model uses change in paw volume of control, test, and standard respectively to find out percentage inhibition of edema. The study revealed that the whole plant of "Inula racemosa" possess a significant anti-diabetic and anti-inflammatory activity.

Keywords


Inula racemosa, Alloxan Induced Diabetes Method, Streptozocin Induced Diabetes Method, Formalin Induced Paw Edema Model, Croton Oil Ear Edema Model.