Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Pathophysiology and Management of Diabetes:A Review


Affiliations
1 Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111(C.G.), India
     

   Subscribe/Renew Journal


Diabetes mellitus is a very common metabolic disorder of endocrine system, every year large Number of people suffered from diabetes. According to recent survey in India about 50.8 million people are suffered from diabetes in 2010, and it will rise to 87.0 million till 2030. For the management and prevention of type 1 and type 2 diabetes different approaches have been done throughout the time In this article we have briefly discuss about evaluation of anti-diabetic activity by the use of different in vivo methods including animal model and in vitro method with special reference to cell line techniques. Article also reflect the evaluation of various anti diabetics phytoconstituents which is obtain from different plant source their activity, mechanism of action and it also highlight the advancement that has been done in past few year by different scientist their work title in different beta cell line technique and what output come from their effort to understand diabetes and to overcome it.

Keywords

Diabetes Mellitus, Pathophysiology, In-Vivo, In-Vitro Method, Treatment.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Duso T, Herr A, Suppliet M. The Welfare Impact Of Parallel Imports: A Structural Approach Applied To The German Market For Oral Anti‐Diabetics. Health economics. 2014 Sep 1; 23(9):1036-57.
  • Tao Z, Shi A, Zhao J. Epidemiological perspectives of diabetes. Cell biochemistry and biophysics. 2015 Sep 1; 73(1):181-5.
  • Kumar PA, Sreedevi V. A Review On Influence Of Antidiabetic Medications On Quality Of Life.
  • Munni JF. Impact of Chronic Diseases on Quality of Life (Doctoral dissertation, East West University).
  • Risérus U, Willett WC, Hu FB. Dietary fats and prevention of type 2 diabetes. Progress in lipid research. 2009 Jan 31; 48(1):4451.
  • Archana C. A survey on Identification of Diabetes Mellitus Patients in Rural Area of Kouluru Village, Panyam Mandal, Kurnool district, Andhra Pradesh.
  • Dawood MH. Comparison of serum alpha amylase level between type one and type two diabetes mellitus among Sudanese in Khartoum state in 2015 (Doctoral dissertation, Sudan University of Science and Technology).
  • Kyu HH, Bachman VF, Alexander LT, Mumford JE, Afshin A, Estep K, Veerman JL, Delwiche K, Iannarone ML, Moyer ML, Cercy K. Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013. bmj. 2016 Aug 9; 354:i3857.
  • DeMasi N. Developing a nutrition education website to increase nutrition knowledge and improve dietary behaviors among California State University, Northridge students (Doctoral dissertation, California State University, Northridge).
  • Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. Jama. 2007 Dec 12; 298(22):2654-64.
  • Belen Sağlam R, TaskayaTemizel T. A framework for automatic information quality ranking of diabetes websites. Informatics for Health and Social Care. 2015 Jan 2; 40(1):45-66.
  • Diabetes Control and Complications Trial. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005 Dec 22;2005(353):2643-53.
  • National Collaborating Centre for Chronic Conditions (Great Britain). Chronic kidney disease: national clinical guideline for early identification and management in adults in primary and secondary care. Royal College of Physicians.
  • Cavanagh PR. Therapeutic footwear for people with diabetes. Diabetes/metabolism research and reviews. 2004 May 1;20(S1).
  • Krentz AJ, Bailey CJ. Oral antidiabetic agents. Drugs. 2005 Feb 1;65(3):385-411.
  • Cheng J, Zhang W, Zhang X, Han F, Li X, He X, Li Q, Chen J. Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis. JAMA internal medicine. 2014 May 1;174(5):773-85.
  • Roopashree TS, Dang R, Rani RS, Narendra C. Antibacterial activity of antipsoriatic herbs: Cassia tora, Momordica charantia and Calendula officinalis. International Journal of Applied Research in Natural Products. 2008 Sep 15;1(3):20-8.2008
  • Ghule BV, Murugananthan G, Nakhat PD, Yeole PG. Immunostimulant effects of Cappariszeyl anica Linn. leaves. Journal of ethnopharmacology. 2006 Nov 24; 108(2):311-5.
  • Dean PM, Matthews EK. Electrical activity in pancreatic islet cells. Nature. 1968 Jul 27; 219(5152):389-90.
  • Gazdar AF, Chick WL, Oie HK, Sims HL, King DL, Weir GC, Lauris V. Continuous, clonal, insulin-and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. Proceedings of the National Academy of Sciences. 1980 Jun 1; 77(6):3519-23.
  • Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P. Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology. 2004 Feb 1; 145(2):667-78.
  • Newgard CB. Cellular engineering and gene therapy strategies for insulin replacement in diabetes. Diabetes. 1994 Mar 1; 43(3):341-50

Abstract Views: 489

PDF Views: 0




  • Pathophysiology and Management of Diabetes:A Review

Abstract Views: 489  |  PDF Views: 0

Authors

Vandna Dewangan
Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111(C.G.), India
Himanshu Pandey
Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111(C.G.), India

Abstract


Diabetes mellitus is a very common metabolic disorder of endocrine system, every year large Number of people suffered from diabetes. According to recent survey in India about 50.8 million people are suffered from diabetes in 2010, and it will rise to 87.0 million till 2030. For the management and prevention of type 1 and type 2 diabetes different approaches have been done throughout the time In this article we have briefly discuss about evaluation of anti-diabetic activity by the use of different in vivo methods including animal model and in vitro method with special reference to cell line techniques. Article also reflect the evaluation of various anti diabetics phytoconstituents which is obtain from different plant source their activity, mechanism of action and it also highlight the advancement that has been done in past few year by different scientist their work title in different beta cell line technique and what output come from their effort to understand diabetes and to overcome it.

Keywords


Diabetes Mellitus, Pathophysiology, In-Vivo, In-Vitro Method, Treatment.

References