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Anti-Inflammatory Activity Screening of Methanolic Extract of Bryophyllum pinnatum Root
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An inflammatory response appears after activation of immune response. Inflammation is a response to remove the primary cause of cell injury. Dead cells, damage tissue sand initiate the repair process. Inflammation may be of two types acute and chronic. Medicinal plants has a potential source of therapeutic aid has a attended a significant role in all over the world for both human and animals not only in the disease condition but also a potential for maintaining a proper health. The plant Bryophyllum pinnatum species (roots) are evaluated for anti-inflammatory activity. Aim: Anti-inflammatory activity of Bryophyllum pinnatum was evaluated using Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Materials and Methods: To prepare methanolic extracts of Bryophyllum pinnatum roots and investigate the anti-inflammatory activity by Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Result: The result obtained indicates that the extract found to have significant (p<0.0001) anti-inflammatory activity in rats. The extract at the test doses 200mg/kg reduced the oedema induced by carrageenan by 41.26% at 3 h, whereas the standard drug showed 47.35% of inhibition ass compared to the control group. Conclusion: The methanolic extract of Bryophyllum pinnatum are safe upto 500mg/kg for continues administration and it can be used as anti inflammatory agent without any harmful effects
Keywords
Inflammation, Oedema, Therapeutic aid, anti-inflammatory activity, Histamine.
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