Research Journal of Pharmacology and Pharmacodynamics

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A Study about the pattern of adverse effects of various oncology drugs in a Tertiary Care Hospital of North East India


Affiliations
1 NETES Institute of Pharmaceutical Science, Mirza, Kamrup, Assam – 781125, India
2 Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam – 781032., India
     

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The aim of the study is to observe the pattern of adverse drug reactions (ADRs) with the usage of various anticancer drugs in a tertiary care hospital of North East India. The study is a prospective, observational evaluation of the ADRs which was conducted over a period of 1 year. During the study period 59 cancer patients receiving chemotherapy were analysed from which a total of 79 ADRs were identified and collected which occurred during and after the cancer treatment. Maximum cases of ADR recorded in the study are mucositis, respiratory disorder, neuropathy, constipation, itching etc. On causality assessment, it was observed that nearly 92% ADRs are considered as possible, 6% are probable and 2% are unlikely. Although, the reporting of ADR is very minimal by the healthcare professionals, this study focuses on the various common ADR associated with the use of anti-cancer agents in the treatment of cancer. The information from the study might be helpful in identifying and minimizing preventable ADRs, while enhancing the knowledge of the healthcare professionals to deal with them more efficiently. Hence the study was done to record and analyze the pattern of adverse drug reaction from oncology drugs

Keywords

Adverse drug reactions, Causality assessment, Pharmacovigilance, chemotherapy.
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  • Kalaiselvan V, Thota P, Singh GN. Pharmacovigilance Programme of India: Recent developments and future perspectives. Indian Journal of Pharmacology. 2016 Nov;48(6):624 doi: 10.4103/0253-7613.194855

  • Shraddha Anil Naik. Review on Pharmacovigilance. Asian J. Pharm. Res. 2020; 10(2):123-128. doi: 10.5958/2231- 5691.2020.00024.6

  • Ragul Viknesh V, Saranya P. Pharmacovigilance - An Overview in a Pharmacist Perspective. Research J. Pharm. and Tech. 2020; 13(8):3941-3946. doi: 10.5958/0974-360X.2020.00697.6

  • Nikita R. Nikam, Rohan R. Vakhariya, Dr. C. S. Magdum. Pharmacovigilance: An Overview. Asian J. Res. Pharm. Sci. 2019; 9(2):107-111. doi: 10.5958/2231-5659.2019.00016.X

  • Archana B. Chavhan, Dipali M. Bhoi. Pharmacovigillance: Drug Safety Monitoring. Asian J. Pharm. Tech. 2019; 9(1):49-52. doi: 10.5958/2231-5713.2019.00009.6

  • Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004 Jul 1;329(7456):15-9. https://doi.org/10.1136/bmj.329.7456.15

  • Patel TK, Patel BP. Incidence of adverse drug reactions in Indian hospitals: a systematic review of prospective studies. Curr Drug Saf. 2016 Apr 1;11(2):128-36. doi: 10.2174/1574886310666150921104523

  • Poddar S, Sultana R, Sultana R, Akbor MM, Azad MA, Hasnat A. Pattern of adverse drug reactions due to cancer chemotherapy in tertiary care teaching hospital in Bangladesh. Dhaka Univ J Pharm Sci 2009;8:11‑6.

  • Surendiran A, Balamurugan N, Gunaseelan K, Akhtar S, Reddy KS, Adithan C. Adverse drug reaction profile of cisplatin‑based chemotherapy regimen in a tertiary care hospital in India: An evaluative study. Indian J Pharmacol 2010;42:40‑3. doi: 10.4103/0253-7613.62412

  • Tran C, Knowles SR, Liu BA, Shear NH. Gender differences in adverse drug reactions. J Clin Pharmacol 1998;38:1003-9. https://doi.org/10.1177/009127009803801103

  • Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs 1995;50:222-39. doi: 10.2165/00003495-199550020-00003

  • Prasad A, Datta PP, Bhattacharya J, Pattanayak C, Chauhan AS, et al. Pattern of adverse drug reactions due to cancer chemotherapy in a tertiary care teaching hospital in Eastern India. J Pharmacovigilance 2013;1:107. http://dx.doi.org/10.4172/jp.1000107

  • Hanlon JT, Ruby CM, Artz M. Geriatrics. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, editors. Pharmacotherapy A Pathophysiologic Approach. 5th ed. New York: McGraw Hill Inc.; 2002. p. 79‑89.

  • Guo, H., Ren, R., Zhang, D. and Ji, M. (2012) Monitoring report on 341 cases of adverse reactions caused by antitumor drugs. Afr J Microbiol Res 6: 3774–3777. https://doi.org/10.5897/AJMR12.359

  • Chopra, D., Rehan, H., Sharma, V. and Mishra, R. (2016) Chemotherapy-induced adverse drug reactions in oncology patients: a prospective observational survey. Ind J Med Paediatr Oncol 37: 42–46. doi: 10.4103/0971-5851.177015

  • Wahlang JB, Laishram PD, Brahma DK, Sarkar C, Lahon J, Nongkynrih BS, et al. Adverse drug reactions due to cancer chemotherapy in a tertiary care teaching hospital. Ther Adv Drug Saf. 2017;8:61–6. https://doi.org/10.1177/204209861667257

  • Shuka SS, Gidwani B, Pandey R, Rao SP, Singh V, Vyas A. Importance of pharmacovigilance in Indian pharmaceutical industry. Asian J Res Pharm Sci. 2012 Mar 28;2(1):4-8. doi: 10.52711/2231-5659

  • Archana B. Chavhan, Dipali M. Bhoi. Pharmacovigillance: Drug Safety Monitoring. Asian J. Pharm. Tech. 2019; 9(1):49-52. doi: 10.5958/2231-5713.2019.00009.6

  • Sumit Kumar, Badruddeen, S. P. Singh, Akhtar Juber, Mohammad Irfan Khan. Evaluation of Dermatological Adverse Drug Reactions in a Tertiary Care Hospital of Northern India. Research J. Pharm. and Tech. 2019; 12(7): 3517-3521. doi: 10.5958/0974- 360X.2019.00598.5

  • S. Kavitha, Rajeswari Vaidyanathan, Vijayaraghavan. A study to assess the effectiveness of care bundle approach on the level of chemotherapy induced peripheral neuropathy and quality of life among patients receiving neurotoxic chemotherapy. Res. J. Pharmacology & Pharmacodynamics. 2018; 10(4): 179-199. doi: 10.5958/2321-5836.2018.00033.2

  • G. Sathyanarayanan, P. Geetha, P. Shanmugasundaram. A Prospective Observational Study on Assessment and Evaluation of Cephalosporin in General Medicine Department at Tertiary Care Hospital. Research J. Pharm. and Tech 2016; 9(8):1039-1042. doi: 10.5958/0974-360X.2016.00197.9

  • Sumit Kumar, Badruddeen, S. P. Singh, Juber Akhtar, Mohammad Irfan Khan, Mohammad Ahmad, Usama Ahmad. Assessment of Analgesics Induced Adverse Drug reactions in a Tertiary Care Hospital. Research J. Pharm. and Tech. 2020; 13(10):4861-4864. doi: 10.5958/0974-360X.2020.00855.0

  • Sayan Kumar Das, Smita Shenoy, Muralidhar Varma, R Rajesh, Ravi Shankar, Sadhana Holla, Kavitha Saravu. A Study of Potential drug-drug interactions in HIV positive individuals with Co-morbidities. Research Journal of Pharmacy and Technology. 2022; 15(5):1960-6. doi: 10.52711/0974-360X.2022.00326.


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  • A Study about the pattern of adverse effects of various oncology drugs in a Tertiary Care Hospital of North East India

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Authors

Lakshyajeet Nath
NETES Institute of Pharmaceutical Science, Mirza, Kamrup, Assam – 781125, India
Urmi Choudhury
Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam – 781032., India
Mangala Lahkar
Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam – 781032., India

Abstract


The aim of the study is to observe the pattern of adverse drug reactions (ADRs) with the usage of various anticancer drugs in a tertiary care hospital of North East India. The study is a prospective, observational evaluation of the ADRs which was conducted over a period of 1 year. During the study period 59 cancer patients receiving chemotherapy were analysed from which a total of 79 ADRs were identified and collected which occurred during and after the cancer treatment. Maximum cases of ADR recorded in the study are mucositis, respiratory disorder, neuropathy, constipation, itching etc. On causality assessment, it was observed that nearly 92% ADRs are considered as possible, 6% are probable and 2% are unlikely. Although, the reporting of ADR is very minimal by the healthcare professionals, this study focuses on the various common ADR associated with the use of anti-cancer agents in the treatment of cancer. The information from the study might be helpful in identifying and minimizing preventable ADRs, while enhancing the knowledge of the healthcare professionals to deal with them more efficiently. Hence the study was done to record and analyze the pattern of adverse drug reaction from oncology drugs

Keywords


Adverse drug reactions, Causality assessment, Pharmacovigilance, chemotherapy.

References