Research Journal of Pharmacology and Pharmacodynamics

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Comparative Phyto and Physico-chemical Standardization of Fresh and Different market samples with the Anti-inflammatory Studies of Fruit Parts of Malva sylvestris L.


Affiliations
1 Research Officer (Chemistry), Drug Standardization Research Unit (Central Council for Research In Unani Medicine), Janakpuri, New Delhi, India
2 Phytopharmaceuticals Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India
     

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Different extracts and the powder of fruits of Malva sylvestris L. (Malvaceae) are traditionally used in the treatment of sore throat, inflammatory chronic bronchitis, jaundice and urinary discharge diseases, and were tested for anti-inflammatory activity in albino rats. The aqueous and ethanol extracts showed significant antiactivity against carrageenan-induced paw oedema. The study includes a comparative Phyto and physicochemical study of fresh and different market samples of the drug, which was carried out under various parameters like successive extractability values, total ash, acid insoluble ash, water soluble ash, alcohol soluble matters, watersoluble matters, pH values of 1% and !0% aqueous solutions, moisture contents, total phenolics, tannins, resins and screening of phytochemical constituents in different extracts. Quantitative elemental analysis by Atomic Absorption Spectrophotometer and the study of characteristics of oil so obtained from petroleum ether extract e.g. saponification value, acid value, peroxide value, ester value, specific gravity, unsaponifiable matter etc. and thin layer chromatography in different extracts were also reported. Beside, the composition of fatty acids was found to be as Lauric (1.87%), Myristic (6.04%), Palmitic (37.53%), stearic (9.93%), Oleic (26.17%), Linoleic (14.36%) and (C20-C22) (4.03%).

Keywords

Anti-inflammatory activity, Physico and Phyto-chemical, Malva sylvestris, Indomethacin, Standardization.
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  • Comparative Phyto and Physico-chemical Standardization of Fresh and Different market samples with the Anti-inflammatory Studies of Fruit Parts of Malva sylvestris L.

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Authors

Akhlaq Mustafa
Research Officer (Chemistry), Drug Standardization Research Unit (Central Council for Research In Unani Medicine), Janakpuri, New Delhi, India
Mohammed Ali
Phytopharmaceuticals Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India

Abstract


Different extracts and the powder of fruits of Malva sylvestris L. (Malvaceae) are traditionally used in the treatment of sore throat, inflammatory chronic bronchitis, jaundice and urinary discharge diseases, and were tested for anti-inflammatory activity in albino rats. The aqueous and ethanol extracts showed significant antiactivity against carrageenan-induced paw oedema. The study includes a comparative Phyto and physicochemical study of fresh and different market samples of the drug, which was carried out under various parameters like successive extractability values, total ash, acid insoluble ash, water soluble ash, alcohol soluble matters, watersoluble matters, pH values of 1% and !0% aqueous solutions, moisture contents, total phenolics, tannins, resins and screening of phytochemical constituents in different extracts. Quantitative elemental analysis by Atomic Absorption Spectrophotometer and the study of characteristics of oil so obtained from petroleum ether extract e.g. saponification value, acid value, peroxide value, ester value, specific gravity, unsaponifiable matter etc. and thin layer chromatography in different extracts were also reported. Beside, the composition of fatty acids was found to be as Lauric (1.87%), Myristic (6.04%), Palmitic (37.53%), stearic (9.93%), Oleic (26.17%), Linoleic (14.36%) and (C20-C22) (4.03%).

Keywords


Anti-inflammatory activity, Physico and Phyto-chemical, Malva sylvestris, Indomethacin, Standardization.

References