Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Antihypertensive Drugs prescribed in West Indian Territories


Affiliations
1 Department of Pharmacy, JJT University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu –333001, Rajasthan, India
     

   Subscribe/Renew Journal


Management of hypertension in patients provides a significant challenge for healthcare professionals. It was convincingly demonstrated that lowering of blood pressure below what is recommended for patients with essential hypertension. The present study was done to find prescription trend in Indian cardiology and nephrology practice and its adherence to therapeutic guidelines. For present study, 120 patients having blood pressure greater or equal to 140/90 mm Hg and fulfilling inclusion-exclusion criteria were enrolled and data of Serum Creatinine and Blood Pressure were recorded at 0 week, 4 week, 8 week and 12 week. In treatment strategy, Goal of blood pressure is to achieve BP up to <130/80 mmHg for all patients. There is still controversy about effectiveness of antihypertensive drugs in CKD. In view of JNC VII guideline, ACE inhibitors should be used as first line treatment. It may surprising in this study that ACE inhibitors or Angiotensin receptor blockers were used only in 50% of the patients, whereas Diuretics were in 87% and Calcium channel blockers were prescribed in 73% patients. It was found that physicians hesitate to prescribe ACE inhibitors as first line treatment due to serious side effects such as brassy cough and hyperkalemia. It was concluded that there is still potential to increase the prescription frequency of ACE inhibitors and AT1 blockers. Management of Hypertension is more difficult in renal patients and requires multi drug therapy, which is further influenced adversely by diabetic condition.

Keywords

Hypertension, ACE Inhibitors, BP, CKD, AT1 Blockers
Subscription Login to verify subscription
User
Notifications
Font Size


  • K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Kidney Disease Outcome Quality Initiative. Am J Kidney Dis 39:S1-S266, 2002 (suppl 2)

  • Yu H.T. Progression of chronic renal failure. Arch Int Med 2003; 163: 1417–1429

  • Brazy P.C., Stead W.W., Fitzwilliam J.F. Progression of renal insufficiency: role of blood pressure. Kidney Int. 1989; 35:670– 674.

  • Walker G.W. Hypertension-related renal injury: a major contributor to end-stage renal disease. Am J Kidney Dis. 1993;22:164 –173

  • Levey A.S. Controlling the epidemic of cardiovascular disease in chronic renal disease: Where do we start? Am J Kidney Dis 1998; 32:S5-S13

  • Klahr S et al. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. N Engl J Med 1994; 330: 877–884

  • Krauss A.G., Hak L.J. Chronic renal disease. In: Herfindal ET, Gourley D.R . Textbook of Therapeutics. Drug and Disease Management, 7th ed. Lippincott Williams and Wilkins: 2000:447–482

  • The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch Int Med 1997; 157: 2413–2446

  • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.

  • Advanced chronic kidney disease (CKD) percent of patients with antihypertensive therapy intensified:National Quality Measures Clearighouse Available: www.qualitymeasures. ahrq.gov


Abstract Views: 264

PDF Views: 0




  • Antihypertensive Drugs prescribed in West Indian Territories

Abstract Views: 264  |  PDF Views: 0

Authors

R. Patel Hirenkumar
Department of Pharmacy, JJT University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu –333001, Rajasthan, India

Abstract


Management of hypertension in patients provides a significant challenge for healthcare professionals. It was convincingly demonstrated that lowering of blood pressure below what is recommended for patients with essential hypertension. The present study was done to find prescription trend in Indian cardiology and nephrology practice and its adherence to therapeutic guidelines. For present study, 120 patients having blood pressure greater or equal to 140/90 mm Hg and fulfilling inclusion-exclusion criteria were enrolled and data of Serum Creatinine and Blood Pressure were recorded at 0 week, 4 week, 8 week and 12 week. In treatment strategy, Goal of blood pressure is to achieve BP up to <130/80 mmHg for all patients. There is still controversy about effectiveness of antihypertensive drugs in CKD. In view of JNC VII guideline, ACE inhibitors should be used as first line treatment. It may surprising in this study that ACE inhibitors or Angiotensin receptor blockers were used only in 50% of the patients, whereas Diuretics were in 87% and Calcium channel blockers were prescribed in 73% patients. It was found that physicians hesitate to prescribe ACE inhibitors as first line treatment due to serious side effects such as brassy cough and hyperkalemia. It was concluded that there is still potential to increase the prescription frequency of ACE inhibitors and AT1 blockers. Management of Hypertension is more difficult in renal patients and requires multi drug therapy, which is further influenced adversely by diabetic condition.

Keywords


Hypertension, ACE Inhibitors, BP, CKD, AT1 Blockers

References