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Assessment of Hypolipidemic Effect of Ardisia solanacea in high fat diet induced rats


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1 SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India
     

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Ardisia solanacea leaves were used for the evaluation of hypolipidemic effects against high fat diet induced hyperlipidemia in rats. The leaves were dried in shade for 20 days, powdered and extracted with Alcohol. Preliminary phytochemical analysis found the presence of phenolic compounds, glycosides and flavonoids in the alcoholic extract. Acute oral toxicity study of alcoholic extract of Ardisia solanacea leaves (AEAS) was conducted in mice by using OECD guideline no.425 and it was found to safe up to the dose label of 2000mg/kg of body weight p.o. The extract at dose of 100 and 200 mg/kg was administered orally once daily for 10 days. Gemfibrozil (50mg/kg p.o.) was used as reference standard. AEAS (200 mg/kg p.o) were potentially reduced average body weight gain and plasma lipids levels including Total cholesterol (TC), Triglycerides (TG), Low density lipoproteins (LDL), Very low-density lipoproteins (VLDL) and enhanced High-density lipoprotein (HDL) level than AEAS (100 mg/kg p.o) while AEAS were reduce plasma glucose levels in a dose dependent manner. The results of this study strongly indicate that AEAS has potent Hypolipidemic effects against high fat diet induced hyperlipidemia in rats.

Keywords

Ardisia solanacea, Hypolipidemia, Cholesterol, HDL, LDL, Triglycerides
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  • Assessment of Hypolipidemic Effect of Ardisia solanacea in high fat diet induced rats

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Authors

Pradeep Kumar Samal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India

Abstract


Ardisia solanacea leaves were used for the evaluation of hypolipidemic effects against high fat diet induced hyperlipidemia in rats. The leaves were dried in shade for 20 days, powdered and extracted with Alcohol. Preliminary phytochemical analysis found the presence of phenolic compounds, glycosides and flavonoids in the alcoholic extract. Acute oral toxicity study of alcoholic extract of Ardisia solanacea leaves (AEAS) was conducted in mice by using OECD guideline no.425 and it was found to safe up to the dose label of 2000mg/kg of body weight p.o. The extract at dose of 100 and 200 mg/kg was administered orally once daily for 10 days. Gemfibrozil (50mg/kg p.o.) was used as reference standard. AEAS (200 mg/kg p.o) were potentially reduced average body weight gain and plasma lipids levels including Total cholesterol (TC), Triglycerides (TG), Low density lipoproteins (LDL), Very low-density lipoproteins (VLDL) and enhanced High-density lipoprotein (HDL) level than AEAS (100 mg/kg p.o) while AEAS were reduce plasma glucose levels in a dose dependent manner. The results of this study strongly indicate that AEAS has potent Hypolipidemic effects against high fat diet induced hyperlipidemia in rats.

Keywords


Ardisia solanacea, Hypolipidemia, Cholesterol, HDL, LDL, Triglycerides

References