Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of antimicrobial and anthelmintic activities of the aerial parts of Elephantopus scaber L.


Affiliations
1 Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, India
2 Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., India
     

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Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. The antimicrobial activities of medicinal plants can be attributed to the secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids that are present in these plants. Helminthes infections are becoming a cause to disorders like eosinophilia, pneumonia, anaemia, and under nourishment. Anti-helmethic drugs will expel these worms by paralyzing or by killing the worms. In traditional system of medicine a large number of plants are claimed to have anthelmintic activity. Chemical study started from 1960's and showed that constituents of E. scaber L. include flavonoids, triterpenoids, flavonoid esters and sesquiterpene lactones. Elephantopus scaber L. belongs to the family Asteraceae. The present study was carried out to screen the antimicrobial and anthelmintic activities of Elephantopus scaber L. The activities of extracts of the plant material are compared with the piperazine citrate. The n-hexane, chloroform and methanolic extracts shows concentration dependent and significant anthelmintic activity compared to the piperazine citrate and Albendazole and Amoxicillin and Fluconazole for the case of antimicrobial activity. Thus the anthelmintic and antimicrobial activities of Elephantopus scaber L. are demonstrated for the first time.

Keywords

Elephantopus scaber L, Antimicrobial Activities, Antihelmethic Drugs, Pheritima posthuma
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  • Thomson, W.A.R., 1978. Medicines from the Earth. Maidenhead, United Kingdom. McGraw-Hill Book Co.

  • Stockwell, C., 1988. Nature’s pharmacy. London, United Kingdom. Century Hutchinson Ltd.

  • Gerhartz, W., Y.S. Yamamota, F.T. Campbell, R. Pfefferkorn and J.F. Rounsaville, 1985. Ullmann’s Encyclopedia of Industrial.

  • Srivastava, J., J. Lambert and N. Vietmeyer, 1996.. Medicinal plants: An expanding role in development. World Bank Technical Paper. No. 320.

  • Uniyal, S.K., K.N. Singh, P. Jamwal and B. Lal, 2006. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalayan. J. Ethnobiol. Ethnomed, 2: 1-14.

  • Reddy PS, Jamil K and Madhusudhan P. Antibacterial activity of isolates from Piper longum and Taxus baccata. Pharma. Biol. 39, 236-238 (2001).

  • Ateb DA and ErdoUrul OT Antimicrobial activities of various medicinal and commercial plant extracts. Turk. J. Biol. 27, 157- 162 (2003).

  • Sher A; Antimicrobial activity of natural products from medicinal plants. Gomal J Med Sci.; 7(1):72-78 (2009)

  • Thorn G.M, Harrison‘s Principles of internal Medicine, 1977, Mc Grew Hill, New York

  • AA Kale et al; JP Salvekara. J. Chem. Pharm. Res., 2011, 3(2), 298-302.

  • Y Shivhare et al J. Chem. Pharm. Res., 2011, 3(1), 488-491.

  • Lee K H, Cowherd C M and Wolo M T. Antitumor agents. XV: deoxyelephantopin, an antitumor principle from Elephantopus carolinianus Willd. J Pharm Sci 1975, 64, 1572–3.

  • Fuchino H, Koide T, Takahashi M, Sekita S and Satake M. New sesquiterpene lactones from Elephantopus mollis and their leishmanicidal activities. Plant Med 2001, 67, 647–53

  • Rajkapoor B, Jayakar B and Anandan R. Antitumor activity of Elephantos scaber Linn. Against Dalton’s Ascitic Lymphoma. Indian J Pharm Sci., 2002, 64, 71 – 73


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  • Evaluation of antimicrobial and anthelmintic activities of the aerial parts of Elephantopus scaber L.

Abstract Views: 353  |  PDF Views: 2

Authors

Lakshmi Kanta Kanthal
Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, India
B. V. V. S. Surya Kiran
Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, India
K. Satyavathi
Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, India
P. Bhoja Raju
Koringa College of Pharmacy, Korangi, Tallarevu [M], E. G. Dist. - 533 461, A.P, India
Subhas Sahoo
Pulla Reddy Institute of Pharmacy, Annaram, Jinnaram (M), Medak Dist., A.P., India

Abstract


Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. The antimicrobial activities of medicinal plants can be attributed to the secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids that are present in these plants. Helminthes infections are becoming a cause to disorders like eosinophilia, pneumonia, anaemia, and under nourishment. Anti-helmethic drugs will expel these worms by paralyzing or by killing the worms. In traditional system of medicine a large number of plants are claimed to have anthelmintic activity. Chemical study started from 1960's and showed that constituents of E. scaber L. include flavonoids, triterpenoids, flavonoid esters and sesquiterpene lactones. Elephantopus scaber L. belongs to the family Asteraceae. The present study was carried out to screen the antimicrobial and anthelmintic activities of Elephantopus scaber L. The activities of extracts of the plant material are compared with the piperazine citrate. The n-hexane, chloroform and methanolic extracts shows concentration dependent and significant anthelmintic activity compared to the piperazine citrate and Albendazole and Amoxicillin and Fluconazole for the case of antimicrobial activity. Thus the anthelmintic and antimicrobial activities of Elephantopus scaber L. are demonstrated for the first time.

Keywords


Elephantopus scaber L, Antimicrobial Activities, Antihelmethic Drugs, Pheritima posthuma

References