Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Anti-depressant Activity of Methanolic Seed Extract of Avena Sativa L. in Mice


Affiliations
1 K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, India
2 T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, India
3 College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, India
     

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The main objective of the study to evaluate the Anti-depressant activity of seeds extract of Avena sativa in Forced swim test (FST), Tail Suspension test (TST) and antagonism of Apomorphine induced hypothermia in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. MSEAS did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, MSEAS showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of MSEAS significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, MSEAS showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission and Antagonism of Apomorphine induced Hypothermia indicating, MSEAS was not acting through Adrenergic system.

Keywords

avena Sativa, Antidepressant Activity, Forced Swim Test, Tail Suspension Test, Antagonising Apomorphine Induced Hypothermia
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  • Evaluation of Anti-depressant Activity of Methanolic Seed Extract of Avena Sativa L. in Mice

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Authors

Praveen Kumar Uppala
K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, India
M. Swarna Latha
K.V.K College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, India
R. Shashidhar Reddy
T.R.R College of Pharmacy, Affiliated to Jawaharlal Nehru Technological University, Hyderabad, India
G. Chakravarthi
College of Pharmaceutical Sciences, Affiliated to Biju Patnaik University of Technology, Rourkela, India

Abstract


The main objective of the study to evaluate the Anti-depressant activity of seeds extract of Avena sativa in Forced swim test (FST), Tail Suspension test (TST) and antagonism of Apomorphine induced hypothermia in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, glycosides, saponins, amino acids, gums and mucilage. MSEAS did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, MSEAS showed diminution of duration of immobility time in 100mg/kg but not in 200mg/kg. In antagonism of Apomorphine induced hypothermia model, Desipramine but not both doses of MSEAS significantly antagonised the Apomorphine induced hypothermia. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, MSEAS showed antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission and Antagonism of Apomorphine induced Hypothermia indicating, MSEAS was not acting through Adrenergic system.

Keywords


avena Sativa, Antidepressant Activity, Forced Swim Test, Tail Suspension Test, Antagonising Apomorphine Induced Hypothermia

References