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In-vitro Biological Screening of Avicennia marina for Anticancer Activity
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Avicenniaceae family is a member of true mangrove plants which has one genus, 11 species and several subspecies. Avicennia marina is the most current species among these plants in many forests attracting many researchers for newer investigation. Regarding to the presence of many active biological constituents in this plant and their applications in traditional and alternative medicine, the in-vitro anticancer activity of its leaf extract on various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T) were determined by XTT bioassay. With use of XTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from XTT bioassay screening revealed that methanolic and aqueous extract of Avicennia marina shown cytotoxicity against HL-60 and NCI-H23 cell line with proficient IC50 values and shown insignificant toxicity against normal cell line (HEK-293T).
Keywords
Avicennia marina, XTT bioassay, anticancer activity, Avicenniacea
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