Research Journal of Pharmacology and Pharmacodynamics

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Diabetes Macroangiopathy - A Review


Affiliations
1 Department of Pharmacology, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, India
2 Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, India
     

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Diabetes mellitus, a metabolic disorder characterised by high levels of blood glucose, is associated with several vascular complications. Although insulin treatment, oral medications, dietary regulations and exercise can delay the development of diabetic microangiopathy, the development of macroangiopathy cannot be prevented solely by glycaemic control. However, diabetic-macroangiopathy refers mainly to an accelerated form of atherosclerosis. This in turn affects both the coronary and cerebral vasculature, thus increasing the risk of myocardial infarction, angina pectoris and cerebrovascular accidents. Diabetes mellitus in humans and animal models of diabetes are associated with impaired endothelium-dependent relaxation i.e. endothelial dysfunction. Endothelial dysfunction, a surrogate marker for the development of diabetic macroangiopathy.

Keywords

Diabetes Mellitus, Endothelial Dysfunction, Hyperglycemia, Oxidative Stress.
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Abstract Views: 253

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  • Diabetes Macroangiopathy - A Review

Abstract Views: 253  |  PDF Views: 2

Authors

K. G. Kanase
Department of Pharmacology, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, India
N. V. Shinde
Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, India
D. K. Bharti
Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, India
V. R. Undale
Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, India
A. V. Bhosale
Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, India

Abstract


Diabetes mellitus, a metabolic disorder characterised by high levels of blood glucose, is associated with several vascular complications. Although insulin treatment, oral medications, dietary regulations and exercise can delay the development of diabetic microangiopathy, the development of macroangiopathy cannot be prevented solely by glycaemic control. However, diabetic-macroangiopathy refers mainly to an accelerated form of atherosclerosis. This in turn affects both the coronary and cerebral vasculature, thus increasing the risk of myocardial infarction, angina pectoris and cerebrovascular accidents. Diabetes mellitus in humans and animal models of diabetes are associated with impaired endothelium-dependent relaxation i.e. endothelial dysfunction. Endothelial dysfunction, a surrogate marker for the development of diabetic macroangiopathy.

Keywords


Diabetes Mellitus, Endothelial Dysfunction, Hyperglycemia, Oxidative Stress.

References