Research Journal of Pharmacology and Pharmacodynamics

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Assessment of Hepatoprotective Activity of Hibiscus vitifolius Leaves in CCL4 Induced Hepatotoxic Rats


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1 SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur Chhattisgarh, India
     

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The objective of this study was to investigate the hepatoprotective activity of alcoholic extract of Hibiscus vitifolius leaves against carbon tetrachloride (CCl4) induced hepatotoxicity. The plant material were dried in shade then powdered and extracted with alcohol. Preliminary phytochemical tests were done. Alcoholic extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the alcoholic extract was assessed in CCl4 induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, Billirubin and Protein were tested in both CCl4 treated and untreated groups. CCl4 (1ml) has enhanced the SGOT, SGPT, ALP and Total Billirubin where decrease in total protein level in liver. Treatment of alcoholic extract of Hibiscus vitifolius (500mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Our findings suggested that Hibiscus vitifolius alcoholic leaves extract possessed hepatoprotective activity.

Keywords

Hibiscus vitifolius, Hepatoprotective, Silymarin, CCl4, Alcohol.
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  • Assessment of Hepatoprotective Activity of Hibiscus vitifolius Leaves in CCL4 Induced Hepatotoxic Rats

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Authors

Pradeep Kumar Samal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur Chhattisgarh, India

Abstract


The objective of this study was to investigate the hepatoprotective activity of alcoholic extract of Hibiscus vitifolius leaves against carbon tetrachloride (CCl4) induced hepatotoxicity. The plant material were dried in shade then powdered and extracted with alcohol. Preliminary phytochemical tests were done. Alcoholic extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the alcoholic extract was assessed in CCl4 induced hepatotoxic rats. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP, Billirubin and Protein were tested in both CCl4 treated and untreated groups. CCl4 (1ml) has enhanced the SGOT, SGPT, ALP and Total Billirubin where decrease in total protein level in liver. Treatment of alcoholic extract of Hibiscus vitifolius (500mg/kg) has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. Our findings suggested that Hibiscus vitifolius alcoholic leaves extract possessed hepatoprotective activity.

Keywords


Hibiscus vitifolius, Hepatoprotective, Silymarin, CCl4, Alcohol.

References