Synthesis and Gastroprotective Evaluation of New Chalcone Derivatives

The etiology of gastrodeodenal ulcers is influenced by various aggressive and defensive factors such as acid pepsin secretion, parietal cells, mucosal barrier, mucous secretion, blood flow, cellular regeneration, endogenous productive agents (PGS and epidermic growth factors), and Helicobacter pylori (H. pylori). However, it has been suggested that free radicals are closely related with peptic ulcer and gastritis. Oxygen free radicals are detrimental to the integrity of biological tissues and mediate their injury. The mechanism of damage involves lipidperoxidation, which destroys cell membranes with the release of intracellular components, such lysosomal enzymes, leading to further tissue damage. The radicals also promote mucosal damage by causing degradation of the epithelial basement membrane components, complete alteration of the cell metabolism and DNA damage. Therefore, by scavenging free radicals, the reactive oxygen metabolites might be useful by protecting the gastric mucosa from oxidative damage or by accelerating healing of gastric ulcer. Antioxidants act as scavengers inhibit lipidperoxidation and other free radicals mediated process, and therefore they protect the human body from several diseases attributed to the reactions of radicals. In this study, the gastroprotective effect of orally administrable newly synthesized chalcone derivatives on gastric lesions by pylorus ligation induced gastric ulcer in rats and In vitro free radical scavenging activity were studied.