Research Journal of Pharmacology and Pharmacodynamics

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Chikungunya Disease: A Review


Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India
2 R. G. Sapakal College of Pharmacy, Nasik, Maharashtra, India
     

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Chikungunya virus is an insect-borne virus, of the genus Alphavirus, that is transmitted to humans by virus-carrying Aedes mosquitoes. The virus causes an illness with symptoms similar to dengue fever with an acute febrile phase of the illness which lasts only two to five days. Infection can affect the nervous system or the musculo-skeletal system. General symptoms include fever, headache, maculopapular rash, arthralgia, myalgia, photophobia and lymphadenopathy. Virus isolation provides the most definitive diagnosis. The most effective means of prevention are protection against contact with the disease-carrying mosquitoes and mosquito control. NSAIDs, chloroquine and DNA vaccine are the effective medicines.

Keywords

Chikungunya, Aedes Mosquitoes, Fever, Chloroquine.
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  • De Lamballerie X, et al.. "Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?". Virol. J. 2008; 5: 33.

  • Powers AM, Logue CH. "Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus" . J. Gen. Virol. 2007; 88: 2363–77.

  • Sourisseau M, Schilte C, Casartelli N, et al. "Characterization of reemerging chikungunya virus". PLoS Pathog. 2007 ; 3 (6): 89.

  • ENVIS News Letter, Issue 2, September, 2006.

  • Robinson MC. "An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features". Trans. R. Soc. Trop. Med. Hyg. 1955; 49 (1): 28–32.

  • Lumsden WH. "An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. II. General description and epidemiology". Trans. R. Soc. Trop. Med. Hyg. 1955; 49 (1): 33–57.

  • Tsetsarkin KA, Vanlandingham DL, McGee Ce et al., "A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential". PLoS Pathog 2007; 3 (12): e201.

  • ProMED-mail; Chikungunya virus: genetic change. ArchiveNumber 2007; 1209-3973.

  • Thai Rath. "Trang hospital found Chikungunya transmitted from a mother to her foetus". 2009

  • Wadia RS. A neurotropic virus (chikungunya) and a neuropathic aminoacid (homocysteine). Annals of Indian Academy of Neurology. 2007 Oct; 10(4): 198-213.

  • Powers AM, Brault AC, Tesh RB, Weaver SC. Reemergence of chikungunya and o’nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. Journal of General Virology. 2000 Feb; 81(Pt 2): 471-9.

  • Strauss, J. H. and Strauss, E. G. Evolution of RNA viruses. Annual Review of Microbiology 1988; 42, 657-683.

  • ProMED. 29 September 2006. V2006#437, 2006a.

  • http://www.who.int/csr/don/2006_02_17a/en/index.html

  • "Safer Healthier People"Centers for Disease Control and Prevention, TTY: (888) 232-6348.

  • World Health Organization/ South-East Asia Regional Office. Chikungunya in South-East Asia-Update, January 2008.

  • World Health Organization. Outbreak and spread of chikungunya. Weekly Epidemiological Record 2007; 82 (47): 409-415.

  • Krishna MR, Reddy MK and Reddy SR. Chikungunya outbreaks in Andhra Pradesh, South India. Current Science 2006; 91(5): 570-571.

  • World Health Organization-South-East Asia Regional Office. Chikungunya Fever, a re-emerging Disease in Asia. http://www.searo.who.int/en/Section10/Section2246.htm accessed 21 October 2008.

  • Chhabra M, Mittal V, Bhattacharya D, Rana U, Lal S (). "Chikungunya fever:". Indian J Med Microbiol 2008; 26 (1): 5–12.

  • Taubitz W, Cramer JP, Kapaun A, et al. "Chikungunya feverin travelers: clinical presentation and course". Clin. Infect. Dis. 2007; 45 (1): e1–4.

  • WHO - Laboratory Diagnosis of Chikungunya Fevers". http://www.searo.who.int/EN/Section10/Section2246_12902.htm. Retrieved 2008-07-11.

  • Chikungunya fever diagnosed among internationaltravelers—United States, 2005-2006". MMWR Morb. Mortal. Wkly. Rep. 55 (38): 1040–2. September 29, 2006.

  • "Chikungunya - Fact sheet". European Centre for Disease Prevention and Control. 2008-01-23.

  • Mahendradas P, Ranganna SK, Shetty R, et al. Ocular manifestations associated with chikungunya. Ophthalmology. 2008 Feb; 115(2):287-91.

  • Kennedy AC, Fleming J, Solomon L. Chikungunya viral arthropathy: a clinical description. Journal of Rheumatology. 1980 Mar-Apr; 7 (2): 231-6.

  • Martin Enserink. "Chikungunya: No Longer a Third World Disease". Science 2007; 318 (5858): 1860–1861.

  • Robinson MC. "An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features". Trans. R. Soc. Trop. Med. Hyg. 1955; 49 (1): 28–32.

  • Edelman R, Tacket CO, Wasserman SS, et al. "Phase II safety and immunogenicity study of livechikungunya virus vaccine TSI-GSD-218". Am. J. Trop. Med. Hyg. June 2000; 62 (6): 681–5.

  • Muthumani K, Lankaraman KM, Laddy DJ, et al. "Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus". Vaccine 2008; 26 (40): 5128–34.

  • Couderc T, Khandoudi N, Grandadam M, et al. Prophylaxis and therapy for Chikungunya virus infection. 2009; 200:516–523.

  • Vanlandingham DL, Hong C, Klingler K, et al. "Differential infectivities of o'nyong-nyong and chikungunya virus isolates in Anopheles gambiae and Aedes aegypti mosquitoes". Am J Trop Med Hyg 2005; 72 (5): 616–21.


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  • Chikungunya Disease: A Review

Abstract Views: 337  |  PDF Views: 2

Authors

N. S. Dighe
Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India
S. R. Pattan
Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India
S. B . Dighe
Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India
S. B. Bhawar
Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India
R. B. Saudagar
R. G. Sapakal College of Pharmacy, Nasik, Maharashtra, India
V. M. Gaware
Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India
M. B. Hole
Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India
V. B. Tambe
Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, India

Abstract


Chikungunya virus is an insect-borne virus, of the genus Alphavirus, that is transmitted to humans by virus-carrying Aedes mosquitoes. The virus causes an illness with symptoms similar to dengue fever with an acute febrile phase of the illness which lasts only two to five days. Infection can affect the nervous system or the musculo-skeletal system. General symptoms include fever, headache, maculopapular rash, arthralgia, myalgia, photophobia and lymphadenopathy. Virus isolation provides the most definitive diagnosis. The most effective means of prevention are protection against contact with the disease-carrying mosquitoes and mosquito control. NSAIDs, chloroquine and DNA vaccine are the effective medicines.

Keywords


Chikungunya, Aedes Mosquitoes, Fever, Chloroquine.

References