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Anti-Inflammatory Activity of a Protease Extracted from the Fruit Stem Latex of the Plant Artocarpus heterophyllus Lam
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The anti-inflammatory activity of the new protease fraction Artocarpain-H extracted from the fruit stem latex of the plant Artocarpus heterophyllus Lam. was evaluated using Carrageenan induced rat paw oedema and Cotton pellet-induced granuloma model. The Artocarpain-H dose dependently inhibited carrageenan induced rat paw edema. It also showed reduction on the granuloma weight in the cotton pellet granuloma method.. In the present investigation, as the test drug is effective in both models of inflammation, there is a possibility that these drugs may be effective in acute and chronic inflammation.
Keywords
Protease, Artocarpain-H, Rat Paw Oedema, Granulom.
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- The wealth of India, A dictionary of Indian Raw Materials and Industrial Products, CSIR, New Delhi. 2000.
- Kritikar K.R., Basu B.D. Indian Medicinal Plants, India Bishen Mahendra Pal Singh, Dehradun 2000.
- Popenoe Wilson. Manual of Tropical and Subtropical Fruits. Hafner Press, New York. 1974.
- Tankard Glenn. Tropical Fruit: an Australian Guide to Growing and Using Exotic Fruits. Viking O’Neil, Australia.1987.
- M. R. Khan et al. Antibacterial activity of Artocarpus heterophyllus. Fitoterapia. 2003; 74( 5): 501-505.
- Feng N. Ko et al. Scavenger and Antioxidant Properties of Prenyl flavones Isolated From Artocarpus Heterophyllus. Free Radical Biology and Medicine. 1998; 25(2): 160-168.
- Wei et al. Anti-inflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis. J. Agric. Food Chem. 2005; 53 (10): 3867-3871.
- Namjuntra P. et al. A sperm-agglutinating lectin from seeds of Jack fruit (Artocarpus heterophyllus). Biochem Biophys Res Commun. 1985; 128(2):833-839.
- Bhattachaeyya A. et al. A kunitz proteinase inhibitor from Archidendron ellipticum seeds: purification, characterization, and kinetic properties. Phytochemistry. 2006; 67(3):232-241.
- Wessel, D. and Flugge, U. I. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 1984; 138(1):141-143.
- Plummer, D.T. An Introduction to Practical Biochemistry, Tata McGraw-Hill Publishing Company Ltd., New Delhi. 1988.
- Lowry O.H. et al. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951; 193: 265-268.
- Litchifield J.T. and Wilcoxan M. A. simplified method of evaluating dose-effect experiments. J. Pharm. Expt. Ther. 1949; 96: 99-113.
- Winter CA et al. Carrageenan induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Expt Biol Med. 1962; 111:544-547.
- D'Arcy et al. The Anti inflammatory action of Griseofulvin in experimental animals. Journal of Pharmacy and Pharmacology. 1960; 12: 659-665.
- Di Rosa M et al. Studies of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. Journal of Pathology. 1971; 104: 15-29.
- Vinegar.R. et al. Biphasic development of carrageenan in rats. J. Pharm. Expt. Ther. 1969; 166: 96-103.
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