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Screening For Wound Healing Activity of Alcoholic Extract of Ocimum kilimandscharicum Leaves
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Objective: To investigate and rationalize the effects of Ocimum kilimandscharicumleaves(Lamiaceae) for their wound healing activity and probable mechanism underlying its protective effects in albino wistar rats.
Methods: The wound healing activity was evaluated using three different types of wound models viz; the excision, incision and dead space wound model. A supportive study was also made on granuloma tissue to estimate the level of hydroxy proline. The healing tissues obtained on the 11th post wounding day of the incision wound model were processed for histological study.
Results: The animals receiving the alcoholic extract of Ocimum kilimandscharicumleaves has shown to possess significant increase in wound closure rate, skin breaking strength, granuloma breaking strength, hydroxy proline content, granuloma dry weight and decrease in mean scar area.
Conclusion: The prohealing potential of the Ocimum kilimandscharicum leaves extract may probably be as a result of the presence of a mixture of phytoconstituents including flavonoids, steroids, etc. and increased collagen deposition as well as better alignment and maturation.
Keywords
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