Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Antihyperlipidemic Activity of Paspalum scrobiculatum L. Grains Extract in Albino Rats


Affiliations
1 Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India
     

   Subscribe/Renew Journal


Pasapalum scrobiculatum also named kodo millet is cultivated as an annual. It has been cultivated for 3000 years in India, where it is considered as a minor cereal crop except in the Deccan. The grains are used as human food: ground into meal and used as puddings. There are some reports that Paspalum scrobiculatum is used traditionally anti-hyperlipidemic plant, but there is no scientific anti-hyperlipidemic activity has been carried out by this plant in rats. The model used to evaluate the anti hyperlipidemic activity were high fat diet induced hyperlipidemic rats, physical parameters like body weights, feed intake, organ weights, biochemical parameters like blood glucose, lipid profile were monitored were monitored. In high fat diet (HFD) induced hyperlipidemia rats treated with HAPS 600mg/kg, 400mg/kg, 200mg/kg, b.w. p.o. (respectively) showed significant decrease in body weights, TG, TC, LDL, VlDL and significant increase in HDL compared to HFD control rats.

Keywords

HFD, HAPS, Paspalum Scrobiculatum, Anti-Hyperlipidemic Activity and Hyperlipidemia.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Varsha D, Shubhangi S, Mangesh P, Naikwade NS. Antihyperlipidemic Activity of Cinnamomum tamala Nees. on high cholesterol diet induced hyperlipidemia. Int J Pharm Tech Res. 2010 Oct-Dec;2(4):2517-21.

  • Raja C, Devender P, Dharam PJ. Antihyperlipidemic agents - a review Indian drugs 1996 Mar;33(3):85-97.

  • Mahley RW, Bersot TP. Drug therapy for hypercholesterolemia and dyslipidemia. In: Brunton LL, editors. Goodman & Gilman's the pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill; 2011. p. 933-48.

  • Sanjay B, Seema S, Kavitha S, Ramesh C, Ashok KK. Synthesis & biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-one as antioxidant & hypolipidemic agents. Bioorganic and med chem. 2000; 8:2195-2209.

  • Richey WN, Caroline M. Is cholesterol lowering therapy worthwhile in the elderly? Emergency medicine (acute medicine for the primary care physician) a monthly, peer-reviewed journal. Cited 2013 Jun 21. Available from: http://www.chelationtherapyonline.com/article/p159.htm.

  • Annon, drug index. New Delhi: passi publication pvt. ltd; 1999. p. 482.

  • Sriram TV. Home remedies; a handbook of herbal cures for common ailments. India: Penguin books; 1998. p.75.

  • Jain S, Bhatia G, Barik R, Kumar P, Jain A, Dixit VK. Antidiabetic activity of Paspalum scrobiculatum Linn. in alloxan induced diabetic rats. J Ethnopharmacol. 2010 Feb 3;127(2):325-8. Cited 2013 Aug 1. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19900528.

  • Shabi MM, Gayathri K, Venkatalakshmi R, Sasikala C. Chemical constituents of hydroalcholic extract and phenolic fraction of Cynodon dactylon. Int J Chem Tech Res. 2010; 2(1):149-154.

  • Kokate CK, Khandelwal KR, Pawar AP, Gohale SB. Practical Pharmacognosy. 3rd Ed. Pune: Nirali Prakashan; 1995. p.137-139.

  • OECD Guidelines for the testing of chemical. Acute oraltoxicity - up and down procedure (UDP). 2008. Cited on 2012 May 25. Available from:http://iccvam.niehs.nih.gov/SuppDocs/FedDocs/OECD/OEC Dtg425.pdf.

  • VetScan Thyroxine (T4)/cholesterol panel - abaxis. Cited 2013 Sep 12. Available from: http://www.abaxis.com/pdf/T4-Cholesterol.pdf.

  • Anti obesity medication. Cited 2013 Aug 13. Available from: http://en.wikipedia.org/wiki/Antiobesity?action=render.

  • Protein: metabolism and effect on blood glucose levels.Franz MJ. Diabetes Educ. 1997 Nov-Dec; 23(6):643. Cited 2013 Aug 18. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9416027.

  • Are you at risk of diabetes? Who gets diabetes. Cited 2013 Aug 20. Available from: http://www.helpguide.org/harvard/understanding_diabetes.htm.

  • Lee MK, Miles PDG, Khoursheed M, Gao KM, Moosa AR and Olefsky JM. Metabolic effects of troglitazone on fructose induced insulin resistance in the rat. Diabetes 1994; 43:1435-39.

  • Anderlova K, Dolezalova R, Housova J, Bosanska L, Haluzikova D, Kremen J, et al. Influence of PPAR-α agonist fenofibrate on insulin sensitivity and selected adipose tissuederived hormones in obese women with type 2 Diabetes. Physiol Res. 2007;56(5):579-86.

  • Umesh K, Patil, S. Saraf and VK Dixit. Hypolipidemic activity of seeds of Cassia tora Linn. J Ethnopharmacol. 2004; 90:249-52.

  • Jiao S, Matsuzawa Y, Matsubara K, Kubo M, Tokunaga K. Abnormalities of plasma lipoproteins in a new genetically obeserat with non-insulin dependent diabetes mellitus (Wistar fattyrat). Int J Obes. 1991; 15:487-95.

  • Watts GF, Jackson P, Mandalia S, Brunt JN, Lewis ES, Coltart DJ, et al. Nutrient intake and progression of coronary artery disease. Am J Cardiol. 1994;73:328-32.

  • Heller F, Harvengt C. Effects of clofibrate, bezafibrate, fenofibrate, and probucol on plasma lipolytic enzymes in normolipidaemic subjects. Eur J Clin Pharmacol. 1983; 23:57-63.

  • Martin G, Schoonjans K, Lefebvre A, Staels B, et al. Coordinate regulation of the expression of the fatty acid transporter protein (FATP) and acyl CoA synthetase (ACS) genes by PPARα and PPARγ activators. J Biol Chem. 1997;272:28210-17.

  • Bradley HF, Salati LM, Goodridge G. Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis. Physiol Rev. 1995;75:47-76.

  • John MD. Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations. The J Nutr. 1998; 128(2):444S-8S.

  • Emily S, Aalst CV, Mieke D T, Maud NV, Jessica R, John JP. Metabolic diseases, clinical, diagnostic and therapeutic aspects of (inherited) hypercholesterolemia. Drug discovery today: Disease mechanisms. 2004 Nov; 1(2):165-70.

  • Curry DL. Effects of mannose and fructose on the synthesis and secretion of insulin. Pancreas 1989; 4(1):2-9.

  • Sandhya T, Dhar SC. Effect of a new herbo - mineral hypolipidemic agent on plasma lipoprotein pattern in rat atherosclerosis. Ind J Exp Biol. 1990 July; 28:657-60.

  • Kuldip S, Jyothi S, Arvindpreet K, Pushpa A. Alteration upon oral ingestion of monosodium glutamate in various lipid and lipoprotein fractions in serum of adult male rat. J Life Sci. 2011; 3(1):17-21.

  • Caslake M, Packard C, Gaw E, Murray E, Griffin B, Vallance B, et al. Fenofibrate and LDL metabolic heterogenicity in hypercholesterolemia. Arterioscler Thromb. 1993;13:702-11.

  • Mann C, Yen F, Grant A, Bihain B. Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. J Clin Invest. 1991;88:2059-66.

  • Vu-Dac N, Schoonjans K, Kosykh V, Dallongeville J, et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. J Clin Invest. 1995;96:741-50.

  • Khanna AK, Riziv F, Chander R. Lipid lowering activity of Phyllanthus niruri in hyperlipidemic rats. J Ethnopharmacol. 2002; 82:19-22.

  • Anura P, Jayasooriya, Masanobu S, Chizuko, et al. Effects of Momordica charantia power on serum glucose levels and various lipid parameters in rats fed with cholesterol free and cholesterol enriched diets. J Ethnopharmacol. 2000;72:331-6.

  • Bhatt GB, Sambaiah K, Chandrasekhara N. The effect of feeding fenugreek and ginger on bile composition in the albino rats. Nutr Rep Int. 1985; 32:1145-51.

  • Lansky PS. plants that lower cholesterol. Acta horticul. 1993; 332:131-6.

  • Mani DN, Bawankule DU, Beerendra K, Saroj. Hyperlipidemic model: studying lipid profile in small experimental animal Int J Pharm Pharm Sci. 2012; 4(3):337.

  • Weidong X, Wang W, Hui S, Dongming X, Guoping C, Lijun D. Hypolipidemic mechanisms of Ananas comosus L. leaves in Mice different from fibrates but similar to statins. J Pharmacol Sci. 2007;103:267-74.

  • Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, et al. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor, Mol Endocrinol. 2005;19:1646-53.


Abstract Views: 375

PDF Views: 0




  • Antihyperlipidemic Activity of Paspalum scrobiculatum L. Grains Extract in Albino Rats

Abstract Views: 375  |  PDF Views: 0

Authors

Satish Narra
Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India
Bandenawaz Ramadurg
Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India
C. D. Saraswathi
Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India

Abstract


Pasapalum scrobiculatum also named kodo millet is cultivated as an annual. It has been cultivated for 3000 years in India, where it is considered as a minor cereal crop except in the Deccan. The grains are used as human food: ground into meal and used as puddings. There are some reports that Paspalum scrobiculatum is used traditionally anti-hyperlipidemic plant, but there is no scientific anti-hyperlipidemic activity has been carried out by this plant in rats. The model used to evaluate the anti hyperlipidemic activity were high fat diet induced hyperlipidemic rats, physical parameters like body weights, feed intake, organ weights, biochemical parameters like blood glucose, lipid profile were monitored were monitored. In high fat diet (HFD) induced hyperlipidemia rats treated with HAPS 600mg/kg, 400mg/kg, 200mg/kg, b.w. p.o. (respectively) showed significant decrease in body weights, TG, TC, LDL, VlDL and significant increase in HDL compared to HFD control rats.

Keywords


HFD, HAPS, Paspalum Scrobiculatum, Anti-Hyperlipidemic Activity and Hyperlipidemia.

References