Research Journal of Pharmacology and Pharmacodynamics

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Antidiabetic Activity of Phragmites karka (Retz.) in Alloxan Induced Diabetic Rats


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1 Dept. of Pharmacology, Gautham College, Bengluru-32, India
     

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Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, and neuropathy causing neurological disorders due to perturbation in utilization of glucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Phragmites karka (Retz), has been claimed to possess antidiabetic properties in Ayurveda medicine system. The present study was undertaken to screen the hypoglycemic activity of methanolic, petroleum ether and aqueous, extracts Phragmites karka (200mg/kg.,b.w.). The methnolic and petroleum ether of Phragmites karka (200mg/kg.,b.w.) showed significant decrease in blood glucose level when compare to aqueous extract of Phragmites karka extract (200mg/kg.,b.w.). It also showed the signifent response in blood serum parameters (albumin, urea, creatnine, and total protein) lipid parameters such as total cholesterol, LDL, HDL, VLDL and TG when compared with diabetic control.

Keywords

Alloxan, Phragmites karka, Diabetes Mellitus, Blood Glucose, Lipid Profile and Blood Serum Parameters.
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  • Antidiabetic Activity of Phragmites karka (Retz.) in Alloxan Induced Diabetic Rats

Abstract Views: 275  |  PDF Views: 0

Authors

C. L. Bharath
Dept. of Pharmacology, Gautham College, Bengluru-32, India
Bandenawaz Ramadurg
Dept. of Pharmacology, Gautham College, Bengluru-32, India

Abstract


Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, and neuropathy causing neurological disorders due to perturbation in utilization of glucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Phragmites karka (Retz), has been claimed to possess antidiabetic properties in Ayurveda medicine system. The present study was undertaken to screen the hypoglycemic activity of methanolic, petroleum ether and aqueous, extracts Phragmites karka (200mg/kg.,b.w.). The methnolic and petroleum ether of Phragmites karka (200mg/kg.,b.w.) showed significant decrease in blood glucose level when compare to aqueous extract of Phragmites karka extract (200mg/kg.,b.w.). It also showed the signifent response in blood serum parameters (albumin, urea, creatnine, and total protein) lipid parameters such as total cholesterol, LDL, HDL, VLDL and TG when compared with diabetic control.

Keywords


Alloxan, Phragmites karka, Diabetes Mellitus, Blood Glucose, Lipid Profile and Blood Serum Parameters.

References