Research Journal of Pharmacology and Pharmacodynamics

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Studies on the Hematological Effect of the Extracts of Cordia dichotoma Forst. F. Fruits


Affiliations
1 Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shimoga-577 202 Karnataka, India
2 Department of Studies in Chemistry, Kuvempu University, Jnana Sahyadri, Shankarghatta, Shimoga-577 451 Karnataka, India
3 Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shimoga-577 202, Karnataka, India
4 Department of Pharmaceutics, H.K.E College of Pharmacy, Gulberga, Karnataka, India
     

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In the present study anti-anaemic effect of the petroleum ether, solvent ether, ethyl acetate, butanol and butanon extracts of Cordia dichotoma Forst.f. fruits was evaluated in albino rats. The rats were made anaemic as per standard procedure and were treated daily by extracts in the dose of 100, 200 and 300 mg/kg body weight for 15 days p.o. After 15 days of daily treatment with the extracts of fruits, the haematological parameters measured are clotting time, bleeding time, hemoglobin content, total count of red blood corpuscles, white blood cells and differential count of leucocytes. From the statistical analysis of the study it has been found that ethyl acetate, butanol and butanon extract of C. dichotoma fruits causes significant dose dependent rise in hemoglobin content and RBC count. However, reduction in clotting and bleeding time was not found to be dose dependent. The WBC count was found to rise only in higher doses of extracts (300mg). In case of higher doses (200 and 300mg/kg body weight) the extracts of fruits reduced the clotting and bleeding time, where as lower dose (100 mg/kg body weight) there was no significant change in bleeding and clotting time. The results suggest that the extracts of C. dichotoma fruits have significant ant-anaemic effect and are haematologically non toxic.

Keywords

Hematological Effect Extracts C. dichotoma forst.f. Fruits.
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  • Studies on the Hematological Effect of the Extracts of Cordia dichotoma Forst. F. Fruits

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Authors

I. J. Kuppast
Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shimoga-577 202 Karnataka, India
P. Vasudeva Nayak
Department of Studies in Chemistry, Kuvempu University, Jnana Sahyadri, Shankarghatta, Shimoga-577 451 Karnataka, India
M. C. Ravi
Department of Pharmacology, National College of Pharmacy, Balraj Urs Road, Shimoga-577 202, Karnataka, India
S. S. Biradar
Department of Pharmaceutics, H.K.E College of Pharmacy, Gulberga, Karnataka, India

Abstract


In the present study anti-anaemic effect of the petroleum ether, solvent ether, ethyl acetate, butanol and butanon extracts of Cordia dichotoma Forst.f. fruits was evaluated in albino rats. The rats were made anaemic as per standard procedure and were treated daily by extracts in the dose of 100, 200 and 300 mg/kg body weight for 15 days p.o. After 15 days of daily treatment with the extracts of fruits, the haematological parameters measured are clotting time, bleeding time, hemoglobin content, total count of red blood corpuscles, white blood cells and differential count of leucocytes. From the statistical analysis of the study it has been found that ethyl acetate, butanol and butanon extract of C. dichotoma fruits causes significant dose dependent rise in hemoglobin content and RBC count. However, reduction in clotting and bleeding time was not found to be dose dependent. The WBC count was found to rise only in higher doses of extracts (300mg). In case of higher doses (200 and 300mg/kg body weight) the extracts of fruits reduced the clotting and bleeding time, where as lower dose (100 mg/kg body weight) there was no significant change in bleeding and clotting time. The results suggest that the extracts of C. dichotoma fruits have significant ant-anaemic effect and are haematologically non toxic.

Keywords


Hematological Effect Extracts C. dichotoma forst.f. Fruits.

References