Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Anti Diabetic Activity of Sida cordifolia Linn of Nilgiris Root on Alloxan Induced Diabetic Rats


Affiliations
1 Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, India
     

   Subscribe/Renew Journal


The aim of the present study was to screen the antidiabetic potential of the ischolar_main of Sida cordifolia linn. In the present study, ischolar_main of Sida cordifolia linn was screened for antidiabetic activity. Root powder of Sida cordifolia was subjected to hot continuous extraction (soxhlet) with various solvents like petroleum ether, (40-600° C), chloroform, butanol, butanone and alcohol. Aqueous extract was prepared by cold maceration. After preliminary phytochemical investigation, all the extracts were evaluated for anti diabetic activity after single dose (acute study) and after prolonged treatment (chronic study in alloxan induced diabetic albino rats. Al thel extracts were given orally at a dose of 250mg/Kg b.w. Glibenclamide was used as standard drug (10mg/Kg b.w. P.o). Alcohol butonal, Chloroform, aqueous and butanone showed significant antidiabetic activity in acute as well as prolonged treatment compared to control. Petrolium ether extract did not show significant anti diabetic activity on prolonged treatment. Among all the extracts, alcoholic extracts had more significantly reduced the blood glucose level after single dose and nearly equal to standard glibenclamide after prolonged treatment.

Keywords

Sida cordifolia, Anti Diabetic, Glibenclamide, Alloxan.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Kirtikar K.R. and Basu B.D, Indian medicinal plant,Iinternational book publishers ,Dehradon, 1999; pp.312

  • Nadkarni A.K, Indian materia medica, popular prakashan pvt limited, Mumbai,. 1982; pp.1135

  • Alam M.Joy S, Anti inflammatory and anti pyretic activity by cotton pellet granuloma formation of alcoholic extract Indian drugs.1991; 28:397

  • Sawhney A N, Khan M R, Anti fungal and anti yeast activity of mathematic extract Pakastian Journal of Scientific . Industrial. Research.1978; 21:193

  • Chaudhury R.R, Gupta, V, Anti fertility activity of sida cordifolia linn Bull . Med. Ethanobot . Research.1980; 1: 420

  • Dhar M. L, Dhar M. M, Anti spasmodic and hypotensive activity by ethanolic extract of sida cordifolia Indian Journal of Experimental. Biology.1968; 6: 232-247

  • Comley J C W , Titanji VPK antifilarial activity by aqueous extract of sida cordifolia , ACTA . Leidensia. 1990; 59:361-363

  • Boily Y Van puyvelde L anti bacterial activity of methanalic extract of plant ,J .Ethano pharmacol. 1986; 16: 1

  • Mukherjee G Banerjee S clinical study of herbal praparation in cases of leucorrhoea calcutta medical journal.,1989;86:133

  • Gunatilaka AAL, Sotheeswaran S, Chandrasekara AI, Badrasriyani HT. Studies on medicinal plants of Sri Lanka, Planta Medica. 1980; 39:66

  • Khan M W, Rashid M A Isolation of fatty acid ester, β sitosterol higher fatty acid including palmatic acid and staric acid from aerial parts of sida cordfolia, Journal of Bangladesh Acadameic Science, 1989; 13:55

  • Sinha S K P, Dogra J V V Isolatio of the flavonoid and saponins from the ischolar_mains and flowers of sida cordifolia, International Journal of Crude drug Research, 1985; 232: 77

  • Chopra RN Premankur D E on preliminary examination of hole plant shows the presence of alkaloid , Indian Journal of medical research., 1930; 18:469

  • Begerhotta. A, Bannerjee N R The polarographic studies indicated that the concentration of ephedrine in perchloric acid extract of sida cordifolia , Current Science, 1985; 54:690

  • Kokate CK practical pharmacognosy Vallaba Prakashan New Delhi. 1994; pp.107-111

  • OECD/OCDE, guidelines for the testing of chemicals, revised drafi guidelines 423; Acute oral toxicity - Acute toxic class method, revised document. 2000

  • Sharma SR, Dwivedi SK, Swarup D, Evalution of anti diabetic activity of plant ischolar_main on alloxan induced diabetic rats International journal of pharmacology 1997; 35: 132-133

  • Geetha M Wahi AK Anti diabetic activity of Barlenia prionitis Journal of natural remedies 2001; 1: 64-66

  • Chude MA Orisakwe OE, Afonne OJ Hypoglycemic effect of the Aq extract of Boerhavia diffusa leaves, Indian journal of pharmacology 2001; 33: 215-216


Abstract Views: 231

PDF Views: 0




  • Anti Diabetic Activity of Sida cordifolia Linn of Nilgiris Root on Alloxan Induced Diabetic Rats

Abstract Views: 231  |  PDF Views: 0

Authors

T. Prabhakar
Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, India
P. K. M. Nagarathna
Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, India
B. S. Vikram
Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, India

Abstract


The aim of the present study was to screen the antidiabetic potential of the ischolar_main of Sida cordifolia linn. In the present study, ischolar_main of Sida cordifolia linn was screened for antidiabetic activity. Root powder of Sida cordifolia was subjected to hot continuous extraction (soxhlet) with various solvents like petroleum ether, (40-600° C), chloroform, butanol, butanone and alcohol. Aqueous extract was prepared by cold maceration. After preliminary phytochemical investigation, all the extracts were evaluated for anti diabetic activity after single dose (acute study) and after prolonged treatment (chronic study in alloxan induced diabetic albino rats. Al thel extracts were given orally at a dose of 250mg/Kg b.w. Glibenclamide was used as standard drug (10mg/Kg b.w. P.o). Alcohol butonal, Chloroform, aqueous and butanone showed significant antidiabetic activity in acute as well as prolonged treatment compared to control. Petrolium ether extract did not show significant anti diabetic activity on prolonged treatment. Among all the extracts, alcoholic extracts had more significantly reduced the blood glucose level after single dose and nearly equal to standard glibenclamide after prolonged treatment.

Keywords


Sida cordifolia, Anti Diabetic, Glibenclamide, Alloxan.

References