Open Access
Subscription Access
Open Access
Subscription Access
Anti-Diarrheal Activity of Methanolic and Aqueous Extracts of Dillenia indica L
Subscribe/Renew Journal
The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.
Keywords
Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.
Subscription
Login to verify subscription
User
Font Size
Information
- Wendel GH, Maria AOM, Guzman JA, Giordano O, Pelzer LE. Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana. Fitoterapia 2008; 79: 1-5.
- Kirtikar KR, Basu BD. Indian medicinal Plants. Lalit M. and Basu, Allahabed, India.1981.
- The wealth of India- A dictionary of Indian Raw Materials and Industrial Products, Volume-III, D-E. National institute of Science communication and information research, CSIR, New Delhi; 2003.
- Shome U, Khanna RK, Sharma HP. Pharmacognostic studies on Dillenia indica Linn. II-Fruit and Seed. Proc. Indian Acad. Sci. (Plant Sci.). 1980; 89:91-104.
- Shome U, Khanna RK, Sharma HP. Pharmacognostic studies on Dillenia indica Linn. I. leaf. Proc. Indian Acad. Sci. 1979; 88: 35-48.
- Banerji N, Majumder P, Dutta NL. A new pentacyclic triterpene lactone from Dillenia indica. Phytochemistry. 1975; 12: 1447-1448.
- Pavanasasivam G, Suktanbawa MU. Flavonoids of some Dilleniaceae species. Phytochemistry. 1975; 14: 1127-1128.
- Abdille MH, Singh RP, Jayaprakash GK, Jena BS. Antioxidant activity of the extracts from Dillenia indica fruits. Food chemistry. 2005; 90: 891-896.
- Yeshwante SB, Juvekar AR, Nagmoti DM, Wankhede SS, Shah AS, Pimprikar RB, Saindane DS. Anti-inflammatory activity of methanolic extract of Dillenia indica L. Leaves. J. Young. Pharmacists. 2009;1:63-66.
- Bhakuni DS, Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN. Screening of Indian plants for biological activity Pt. II. Ind J Exp bio. 1968; 7: 250-262.
- O.O. Adeyemi OO, Akindele AJ. Antidiarrhoeal activity of the ethyl acetate extract of Baphia nitida (Papilionaceae). J. Ethnopharmacol. 2008;116: 407-412.
- Rang HP, Dale MM, Ritter JM. Textbook of Pharmacology. UK: Churchill Livingstone; 1999
- Mukherjee PK, Saha K, Murugesan T, Mandal SC, Pal M, Saha BP. Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India. J. Ethnopharmacol. 1998;60:85-89
- Capasso F, Mascolo N, Izzo AA, Gaginella TS. Dissociation of castor oil-induced diarrhoea, and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester. Br. J. Pharmacol. 1994;113:1127-1130.
- Mbagwu HOC, Adeyemi OO. Anti-diarrhoeal activity of the aqueous extract of Mezoneuron benthamianum Baill (Caesalpiniaceae). J. Ethnopharmacol. 2008;116:16-20.
Abstract Views: 290
PDF Views: 0