Research Journal of Pharmacology and Pharmacodynamics

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Gastroesophageal Reflux Disease: Pathophysiology and Treatments Available


Affiliations
1 Rajendra Institute of Technology and Sciences, Sirsa Haryana, India
2 Chitkara School of Pharmaceutical Sciences, Chitkara University, Barotiwala HP, India
3 NCRD's Sterling Institute of Pharmacy, Navi Mumbai, India
     

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Gastroesophageal reflux disease (GERD) is primarily a motility disorder. Escape of gastric contents into the esophagus occurs as a consequence of an incompetent gastroesophageal barrier. This barrier is weakened in the presence of an abnormally functioning Lower Esophageal Sphincter (LES). This review is focused on the epidemiology, pathophysiology and treatments of gastro-oesophageal reflux disease.

Keywords

Reflux, Proton Pump Inhibitors, H2 Receptor Antagonists, Radiofrequency.
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  • Gastroesophageal Reflux Disease: Pathophysiology and Treatments Available

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Authors

Pankaj Rakha
Rajendra Institute of Technology and Sciences, Sirsa Haryana, India
Raj Kumar
Rajendra Institute of Technology and Sciences, Sirsa Haryana, India
Supriya
Rajendra Institute of Technology and Sciences, Sirsa Haryana, India
Nidhi
Rajendra Institute of Technology and Sciences, Sirsa Haryana, India
Manju Nagpal
Chitkara School of Pharmaceutical Sciences, Chitkara University, Barotiwala HP, India
Gitika Arora
NCRD's Sterling Institute of Pharmacy, Navi Mumbai, India

Abstract


Gastroesophageal reflux disease (GERD) is primarily a motility disorder. Escape of gastric contents into the esophagus occurs as a consequence of an incompetent gastroesophageal barrier. This barrier is weakened in the presence of an abnormally functioning Lower Esophageal Sphincter (LES). This review is focused on the epidemiology, pathophysiology and treatments of gastro-oesophageal reflux disease.

Keywords


Reflux, Proton Pump Inhibitors, H2 Receptor Antagonists, Radiofrequency.

References