Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Genotoxic Effect of Cashew Nut Kernel Oil


Affiliations
1 East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore - 560 049, India
2 East Point College of Pharmacy, # 147, Bidarahalli, Virgonagar Post, Bangalore - 560 049, India
3 NGSM Institute of Pharmaceutical Sciences, Palneer, Mangalore - 575 005, India
     

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The present study has been carried out to investigate the genotoxic effect of Cashew nut kernel oil by Drosophila melanogaster (fruit fly) and on Allium cepa ischolar_main (meristamatric tip) methods. Different concentration of Cashew nut kernel oil in ethanol were selected and subjected for sterility test and dominant lethal test by using Drosophilla. For Allium cepa method, each concentration of test oil was applied for different times 12h, 24h and 48h. The obtained result indicates that the cashew nut kernel oil had the ability to cause genotoxic effect at 0.03% v/v concentration in ethanol and also cause different mitotic changes. These various changes appeared in depending on the duration of treatment. The results obtained from both sterility test and dominant lethal test found that Cashew nut kernel oil increases the lethality in flies while the concentration of oil increases.

Keywords

Alliumcepa, Cashew Nut Kernel Oil, Drosophila, Chromosome Abnormalities.
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  • Evaluation of Genotoxic Effect of Cashew Nut Kernel Oil

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Authors

S. G. Keshavamurthy
East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore - 560 049, India
Dey Tathagata
East Point College of Pharmacy, # 147, Bidarahalli, Virgonagar Post, Bangalore - 560 049, India
V. Suresh
East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore - 560 049, India
Jacob Jincy
East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore - 560 049, India
C. S. Shastry
NGSM Institute of Pharmaceutical Sciences, Palneer, Mangalore - 575 005, India

Abstract


The present study has been carried out to investigate the genotoxic effect of Cashew nut kernel oil by Drosophila melanogaster (fruit fly) and on Allium cepa ischolar_main (meristamatric tip) methods. Different concentration of Cashew nut kernel oil in ethanol were selected and subjected for sterility test and dominant lethal test by using Drosophilla. For Allium cepa method, each concentration of test oil was applied for different times 12h, 24h and 48h. The obtained result indicates that the cashew nut kernel oil had the ability to cause genotoxic effect at 0.03% v/v concentration in ethanol and also cause different mitotic changes. These various changes appeared in depending on the duration of treatment. The results obtained from both sterility test and dominant lethal test found that Cashew nut kernel oil increases the lethality in flies while the concentration of oil increases.

Keywords


Alliumcepa, Cashew Nut Kernel Oil, Drosophila, Chromosome Abnormalities.

References