Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Evaluation of Immunomodulatory Activity of Aqueous Extract of the Bulb of Allium sativam in Wistar Rats


Affiliations
1 School of Pharmacy, CEC, Bilaspur - 495009, Chhattisgarh, India
     

   Subscribe/Renew Journal


There is no effective drug for treatment of certain infections like AIDS, hepatitis, and other viral infections. For other infections the drug (mainly antibiotics) being used are becoming ineffective due to development of microbial resistance, necessitating the search for newer drugs. Any such new drug will be available only at an exorbitant cost due to the product patent norms under WTO agreement. This work is to prove the immunomodulatory property of Allium sativam in wistar rats by studying the Delayed Type Hypersensitivity (DTH), Humoral Antibody titre (HA), Total Leukocyte Count (TLC), and Differential Leukocyte Count (DLC) In The Aqueous Extract of Allium sativam. bulbs. The effect of this extract were comparable to the standards drug Levamisole all the data represents the Immunostimulatory activity of aqueous extract of the bulb of Allium sativam.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Neelam Makare, Subhash Bodhankar*, Vindo Rangari., "Immunomodulatyory activity of alcoholic extract of Allium sativam L. in mice" Jounrla of Ethno Pharmacology Vol. 78(2001) p.no.133-137.

  • Kulkarni SR, Karandevs. Study of Immunostimulant activity Indian, Drugs 1998: 35: 427-33.

  • DM. Weir "Hanbook"of experimentla immunology" Vol.2 editor D.M. Weir Balckwell scientific publication, London (1986) IVth edn p.no 3. 922-39.23.

  • Pallabi DE, Dasgupta SC, Gomes A Immuno Potentiating activity of Immune-21;A Polyherbal product. Indian J Pharmacol 1998; 30:163.

  • LaGangre, P.H., Makaness, G.B., Miller, T.E., 1974. "Potentiation of cell mediated immunity by selective suppression of antibopdy formation with cyclophosphamide", Journal of experimental Medicines Vol. 139 p.no 1529-1539.

  • P. K. Mediratta, K.K. Sharma, Surrendersingh."Evaluaiton of Immunomodulatory potential of Occium sanctium seed oil end its possible mechanism of action", Journal of Ethno Pharmacology Vol. 80 (2002) p.no. 15-20.

  • Leemol Davis, Girija Kuttan., " Immunomodulatory activity of Withania Somnifera", Journal of Ethno pharmacology Vol. 71 (2000) p.no. 193-200.

  • Benacerraf, B. 1978. "A hypothesis to relate the specificity of Tlymphocytes and the activity of I region specific Ir genes in macrophages and B lymphocytes", Journal of Immunology Vol. 120 p.no. 1809-1812.

  • Atal, C.K., Ssharma, M.L., Kaul, A., Khajuria, A., 1986 "Immunomodulatory agents of plant origin I: preliminary screening", Journal of Ethno Pharmacology, Vol. 18 p.no. 133-141.

  • Puri, A., Saxena. R.P., Saxena, K.C., Srivastava, V., Tandon, J.S., 1994., "Immunostimulant activity of Nyctanthes arbortristis L. Journal of Ethnopharmacology" Vol. 42, pno. 31-37.


Abstract Views: 256

PDF Views: 2




  • Evaluation of Immunomodulatory Activity of Aqueous Extract of the Bulb of Allium sativam in Wistar Rats

Abstract Views: 256  |  PDF Views: 2

Authors

M. P. Singh
School of Pharmacy, CEC, Bilaspur - 495009, Chhattisgarh, India
R. Jaiswal
School of Pharmacy, CEC, Bilaspur - 495009, Chhattisgarh, India
S. Mandal
School of Pharmacy, CEC, Bilaspur - 495009, Chhattisgarh, India

Abstract


There is no effective drug for treatment of certain infections like AIDS, hepatitis, and other viral infections. For other infections the drug (mainly antibiotics) being used are becoming ineffective due to development of microbial resistance, necessitating the search for newer drugs. Any such new drug will be available only at an exorbitant cost due to the product patent norms under WTO agreement. This work is to prove the immunomodulatory property of Allium sativam in wistar rats by studying the Delayed Type Hypersensitivity (DTH), Humoral Antibody titre (HA), Total Leukocyte Count (TLC), and Differential Leukocyte Count (DLC) In The Aqueous Extract of Allium sativam. bulbs. The effect of this extract were comparable to the standards drug Levamisole all the data represents the Immunostimulatory activity of aqueous extract of the bulb of Allium sativam.

References