Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Healing Potential of Trichosanthes dioica Roxb on Burn Wounds


Affiliations
1 Dept. of Pharmacognosy, VNS Institute of Pharmacy, Bhopal (M.P.), India
2 Dept. of Pharmacognosy, VNS Institute of Pharmacy, Bhopal M.P., India
     

   Subscribe/Renew Journal


Trichosanthes dioica Roxb is a well-known plant in the traditional medicine. Based on its traditional use, methanolic extract of the plant was selected for assessment of healing potential in the form of simple ointment using full thickness burn wound model in rats. The effect produced by the extract ointment showed significant healing when compared with the control and standard groups. All parameters such as wound contraction, epithelialization period, hydroxyproline content, and histopathological studies were observed significant (P<0.01) in comparison to control group.

Keywords

T. dioica, Burn Wound, Hydroxyproline.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Patil MB, Jalalpure SS and Nagoor VS. Wound healing activity of the ischolar_mains of Eclipta Alba LINN. Indian Drugs. 2004; 41(1): 40-45.

  • Mokaddas E, Rotimi VO and Sanyal SC. In vitro activity of piperacillin/tazobactam versus other broad antibiotics against nosocomial gram negative pathogens isolated from burn patients. Journal of Chemotherapy. 1998; 10 (3): 208-214.

  • Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998; 157-161.

  • Diwan PV, Tillo LD and Kulkarni DR. Influence of Tridax procumbens on wound healing. Indian Journal of Medical Research. 1982; 75: 460-464.

  • Nagappa AN and Cheriyan B. Wound healing activity of the aqueous extract of Thespesia populnea fruit. Fitoterapia 2001; 72: 503-506.

  • Rasik AM, Raghubir R, Gupta A, Shukla A, Dubey MP, Srivastava S, Jain HK and Park Kulshrestha DK. Healing potential of Calotropis procera on dermal wounds in guinea pigs. Journal of Ethnopharmacology. 1999; 68: 261-266.

  • Suguna L, Sivakumar P and Chandrakasan G. Effects of Centella asoatica extract on dermal wound healing in rats. Indian Journal of Experimental Biology. 1996; 34: 1208-1211.

  • Chaterjee Asima and Pakrashi Satyesh Chandra. The Treatise of Indian Medicinal Plants, Vol. 1, Publication and Information Directorate, New Delhi, 1994.

  • Kirtikar KR and Basu BD. Indian Medicinal Plants. Allahabad, India. 1956.

  • Rai PK, Jaiswal D, Diwakar S and Watal G. Antihyperglycemic profile of Trichosanthes dioica seeds in experimental models. Pharm Biol. 2008; 46 (5): 1-6.

  • Sharma G and Pant MC. Effect of feeding Trichosanthes dioica (Parval) whole fruits on blood glucose, serum triglycerides, phospholipid, cholesterol and high density lipoprotein-cholesterol levels in the normal albino rabbits. Current Science. 1988; 57: 1085-87.

  • Cooper. Gunn's Dispensing for pharmaceutical students. CBS Publisher and Distributors, Delhi. 1987.

  • K. Shanmuga Priya, Gnanamani A, Radhakrishnan N and Mary Babu. Healing potential of Datura alba on burn wounds in albino rats. Journal of Ethanopharmacology. 2002; 83: 193-199.

  • Sadaf F, Saleem R, Ahmed M, Ahmad SI and Navaid-ul- Zafar. Healing potential of cream containing extract of Sphaeranthus indicus on dermal wounds in Guinea pigs. Journal of Ethnopharmacology. 2006; 107: 161-163.

  • Rashed AN, Afifi FU and Disi AM. Simple evaluation of wound healing activity of a crude extract of Portuloca oleracea Linn. (growing in Jordan) in Mus musculus JVI-1. Journal of Ethanopharmacology. 2003; 88: 131-136.

  • Woessner JF. The determination of hydroxyproline in tissue and protein samples containing small portion of this imino acid. Archives of Biochemistry and Biophysics. 1961; 193: 440-447.

  • McManus JFA and Mowry RW. Staining Methods, Histological and Histochemical. Harper & Row/Evanston, New York/London. 1965.

  • Tsuchiya H, Sato M, Miyazaki T, Fujiwara S, Tanigaki S and Ohyama M. Comparative study on the antibacterial activity of phytochemical flavanones against methicillin- resistant staphylococcus aureus. Journal of Ethanopharmacology. 1996; 50: 27-34.

  • Scortichini M. and Pia Rossi M. Preliminary in vitro evaluation of the antimicrobial activity of terpenes and terpenoids towards Erwinia amylovora (Burrill). J. Appl Bacteriol. 1991; 71: 109-12.

  • Goren N, Woerdenbag H and Bozok- Johanssan C. Cytotoxic and antibacterial activities of sesquiterpene lactones isolated from Tanacetum praeteritum. Planta medica. 1996. 62: 419-22.


Abstract Views: 332

PDF Views: 1




  • Healing Potential of Trichosanthes dioica Roxb on Burn Wounds

Abstract Views: 332  |  PDF Views: 1

Authors

Yogesh Shivhare
Dept. of Pharmacognosy, VNS Institute of Pharmacy, Bhopal (M.P.), India
Priya Singh
Dept. of Pharmacognosy, VNS Institute of Pharmacy, Bhopal M.P., India
U. K. Patil
Dept. of Pharmacognosy, VNS Institute of Pharmacy, Bhopal M.P., India

Abstract


Trichosanthes dioica Roxb is a well-known plant in the traditional medicine. Based on its traditional use, methanolic extract of the plant was selected for assessment of healing potential in the form of simple ointment using full thickness burn wound model in rats. The effect produced by the extract ointment showed significant healing when compared with the control and standard groups. All parameters such as wound contraction, epithelialization period, hydroxyproline content, and histopathological studies were observed significant (P<0.01) in comparison to control group.

Keywords


T. dioica, Burn Wound, Hydroxyproline.

References