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Local Anaesthetic Activity of Calotropis gigantea Latex in Frog and Guinea Pig
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This work evaluated the local anaesthetic activity of milky latex obtained from Calotropis gigantea using three different experimental models in frog and Guinea pig. The latex at dilution 1:10 showed the anaesthetic activity compared to the standard drug xylocaine (0.2%). The methods used are nerve block or lumbar plexus anaesthesia and muscle twitch in frog, infiltration anaesthesia in Guinea pig. It was concluded that latex of Calotropis gigantea (1:10 dilution ) exhibited significant local anaesthetic activity.
Keywords
Calotropis Gigantea, Milky Latex, Local Anaesthetic Activity, Nerve Block Method, Muscle Twitch Method and Infiltration Method.
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