Research Journal of Pharmacology and Pharmacodynamics

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Evaluation of Antiulcer Activity of Piper betel Leaves Extract in Rats


Affiliations
1 Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411001, Maharashtra, India
2 Department of Pharmacology, Faculty of Pharmacy, Dharamsinh Desai University, College Road, Nadia-387001, Gujarat, India
3 Indira College of Pharmacy, Pune, Maharashtra, India
4 Poona College of Pharmacy & Research Centre, Pune, India
     

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In Indian traditional system of medicine, the leaves of Piper betel are recommended for the management of peptic ulcer. In light of this, the antiulcer activity of hydroalcoholic extract of Piper betel (HEPB) leaves was evaluated in rats employing the HCl-ethanol, acute stress and pylorus ligation models to induce the experimental gastric ulcers. Pretreatment with Piper betel extract provided significant ulcer protective effect in all the experimental models along with significant increase in gastric pH and decrease in gastric fluid volume. Thus, it can be concluded that hydroalcoholic extract of Piper betel leaves possesses antiulcer activity which can be attributed to its putative mechanism of action.

Keywords

Acute Stress, Antiulcer Activity, HCl-Ethanol, Piper Betel, Pylorus Ligation.
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  • Evaluation of Antiulcer Activity of Piper betel Leaves Extract in Rats

Abstract Views: 330  |  PDF Views: 1

Authors

Neeraj S. Vyawahare
Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411001, Maharashtra, India
Virendra G. Kagathara
Department of Pharmacology, Faculty of Pharmacy, Dharamsinh Desai University, College Road, Nadia-387001, Gujarat, India
R. G. Katedeshmukh
Indira College of Pharmacy, Pune, Maharashtra, India
Pushpendra K. Sharma
Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411001, Maharashtra, India
Smeeta M. Mohod
Poona College of Pharmacy & Research Centre, Pune, India

Abstract


In Indian traditional system of medicine, the leaves of Piper betel are recommended for the management of peptic ulcer. In light of this, the antiulcer activity of hydroalcoholic extract of Piper betel (HEPB) leaves was evaluated in rats employing the HCl-ethanol, acute stress and pylorus ligation models to induce the experimental gastric ulcers. Pretreatment with Piper betel extract provided significant ulcer protective effect in all the experimental models along with significant increase in gastric pH and decrease in gastric fluid volume. Thus, it can be concluded that hydroalcoholic extract of Piper betel leaves possesses antiulcer activity which can be attributed to its putative mechanism of action.

Keywords


Acute Stress, Antiulcer Activity, HCl-Ethanol, Piper Betel, Pylorus Ligation.

References