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Screening of Some Indigenous Plants for Their Antipyretic Activity
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In the present study, aqueous extract of leaves of Capparis zeylanica Linn, Annona reticulata Linn and Clerodendron phlomidis Linn were given at a dose of 200mg/kg, 400mg/kg (p.o.).
The antipyretic activity was done after inducing hyperpyrexia by injecting subcutaneously 20% aqueous suspension of Brewer's yeast in rats. Rats developing 0.5° C-1° C or more rises in rectal temperature 18 h after injection were taken for study.
The results proved that the aqueous extract of leaves of Clerodendron phlomidis Linn and Annona reticulata Linn has significant antipyretic activity and were compared with paracetamol (150 mg/kg body weight, p.o.), a standard antipyretic agent. Aqueous extract of leaves of Capparis zeylanica Linn has not reduced elevated fever in experimental rats.
Keywords
- Shastri BM. The wealth of India. A dictionary of Indian raw materials & industrial products. CSIR, New Delhi. 1995.
- Kritikar KR. and Basu BD. Indian medicinal plants. Vol.II. Lalit mohan Basu Prakashan, Allahabad. 1933.
- Nadkarni KM. Indian Materia medica, Popular Prakashan, Bombay. 1982.
- Loux JJ, Depalma PD, Yankell SL. Antipyretic testing of aspirin in rats, Toxicol Appl Pharmacol. 1972; 2: 672-5.
- Murugesan, T.,et al. Evaluation of Antipyretic potential of Jussiaea suffruticosa Linn. Extract in rat. Phytomedicine. 2000; 7(3): 231.
- Subrata K. et. al. Antipyretic activity of Eupatorium adenophorum leaf extract, Indian J. Nat. Prod. 2005; 21(1): 16-17.
- Kulkarni SK. Handbook of Experimental Pharmacology. Vallabh Prakashan, II Edition Delhi. 1993.
- Gerhard HV and Wolf HV. Drug Discovery and Evaluation of Pharmacological assays Springer-Verla, New York. 1997; 1st Edn.: PP.390-418.
- Bolton S and Bon C. Pharmaceutical statistics, Marcel Dekker Publication, Blacksburg. 2004; 4st edition: P.437.
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