Research Journal of Pharmacology and Pharmacodynamics

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Pharmacological Investigation of Protective Effects of Euphorbia hirta Whole Plant Extract, Against Duodenal Ulceration in Wistar Rats


Affiliations
1 GRY Institute of Pharmacy, Borawan, Khargone, MP-451228, India
2 University Department of Pharmaceutical Sciences, Utkal University-751004, Orissa, India
     

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Objective: The plant Euphorbia hirta is used in gastrointestinal disorders and used as an anti bacterial, anti fungal and having wound healing property. The present study was carried out to evaluate the effect of Euphorbia hirta whole plant (ethanolic and aqueous extract p.o.) on gastric and duodenal ulceration.

Materials and Methods: The study was carried out on duodenal ulceration model. The duodenal ulcers were induced by using Cysteamine hydrochloride (450 mg/kg). Ranitidine (20 mg/kg) was used as standard drug. Then the aqueous extract (300mg/kg) and ethanolic (250mg/kg) of the plant is used as the test drug, which is compared against the potent duodenal ulcer causing agent Cysteamine hydrochloride.

Results: Both the extracts of the plant Euphorbia hirta showed potent duodenal ulcer healing effect in Cysteamine induced duodenal ulceration. The aqueous extract of the plant Euphorbia hirta showed potent activity than ethanolic extract. Conclusion: The plant Euphorbia hirta Linn. Increases healing of duodenal ulceration and prevents the development of experimentally induced duodenal ulceration in rats.

Conclusion: The plant Euphorbia hirta Linn. Increases healing of duodenal ulceration and prevents the development of experimentally induced duodenal ulceration in rats.


Keywords

Duodenal Ulceration, Cysteamine Hydrochloride, Buffered Formaldehyde, Paraffin, Hematoxylin, Eosin.
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  • Pharmacological Investigation of Protective Effects of Euphorbia hirta Whole Plant Extract, Against Duodenal Ulceration in Wistar Rats

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Authors

Prabhat K. Das
GRY Institute of Pharmacy, Borawan, Khargone, MP-451228, India
Sabuj Sahoo
University Department of Pharmaceutical Sciences, Utkal University-751004, Orissa, India
Ranjan Sethi
GRY Institute of Pharmacy, Borawan, Khargone, MP-451228, India
Praveen S. Nayak
GRY Institute of Pharmacy, Borawan, Khargone, MP-451228, India
Shweta Nayak
GRY Institute of Pharmacy, Borawan, Khargone, MP-451228, India

Abstract


Objective: The plant Euphorbia hirta is used in gastrointestinal disorders and used as an anti bacterial, anti fungal and having wound healing property. The present study was carried out to evaluate the effect of Euphorbia hirta whole plant (ethanolic and aqueous extract p.o.) on gastric and duodenal ulceration.

Materials and Methods: The study was carried out on duodenal ulceration model. The duodenal ulcers were induced by using Cysteamine hydrochloride (450 mg/kg). Ranitidine (20 mg/kg) was used as standard drug. Then the aqueous extract (300mg/kg) and ethanolic (250mg/kg) of the plant is used as the test drug, which is compared against the potent duodenal ulcer causing agent Cysteamine hydrochloride.

Results: Both the extracts of the plant Euphorbia hirta showed potent duodenal ulcer healing effect in Cysteamine induced duodenal ulceration. The aqueous extract of the plant Euphorbia hirta showed potent activity than ethanolic extract. Conclusion: The plant Euphorbia hirta Linn. Increases healing of duodenal ulceration and prevents the development of experimentally induced duodenal ulceration in rats.

Conclusion: The plant Euphorbia hirta Linn. Increases healing of duodenal ulceration and prevents the development of experimentally induced duodenal ulceration in rats.


Keywords


Duodenal Ulceration, Cysteamine Hydrochloride, Buffered Formaldehyde, Paraffin, Hematoxylin, Eosin.

References