Research Journal of Pharmacology and Pharmacodynamics

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Recent Targets in Drug Discovery: A Review


Affiliations
1 Siddhi Vinayaka Institute of Technical Sciences, Mangla, Bilaspur, Chhattisgarh, India
2 Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur, Chhattisgarh, India
3 School of Pharmaceutical Sciences, Siksha O Anushandhan University, Bhubneshwar, Orissa, India
     

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Drug design and drug discovery have critical importance in human health care. There are various sites for the drug targeting like cell membrane, intracellular constituents, outside the cell and possibly antimicrobial action. Receptor as agonist and antagonist, enzymes and pumps, ion channels, physicochemical action with Lipid, protein or water constituents of nerve cell membrane are targeted on cell membrane. Various type of nuclear receptor like Oestrogen, retinoid, vitamin-D, Glucocorticoid, Thyroid hormone, peroxisome proliferators, liver receptor etc. are targeted on the intracellular constituents. The traditional approach of drug discovery involves target identification, validation, lead search and optimization followed by clinical development phases. The recent targets for drug action are DNA, Nuclear Receptors e.g. Retinoid Receptors, Ion Channels e.g. Calcium channel, Enzymes e.g. Cholinesterase, Receptors e.g. Adenosine Receptor in the present work different targets of drug action are discussed in brief which is an essential part during discovery phase of a drug.

Keywords

Drug Design, Drug Discovery, Receptors, Targets.
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  • Recent Targets in Drug Discovery: A Review

Abstract Views: 285  |  PDF Views: 2

Authors

Shweta Paroha
Siddhi Vinayaka Institute of Technical Sciences, Mangla, Bilaspur, Chhattisgarh, India
Ravindra Dhar Dubey
Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur, Chhattisgarh, India
Subrata Mallick
School of Pharmaceutical Sciences, Siksha O Anushandhan University, Bhubneshwar, Orissa, India

Abstract


Drug design and drug discovery have critical importance in human health care. There are various sites for the drug targeting like cell membrane, intracellular constituents, outside the cell and possibly antimicrobial action. Receptor as agonist and antagonist, enzymes and pumps, ion channels, physicochemical action with Lipid, protein or water constituents of nerve cell membrane are targeted on cell membrane. Various type of nuclear receptor like Oestrogen, retinoid, vitamin-D, Glucocorticoid, Thyroid hormone, peroxisome proliferators, liver receptor etc. are targeted on the intracellular constituents. The traditional approach of drug discovery involves target identification, validation, lead search and optimization followed by clinical development phases. The recent targets for drug action are DNA, Nuclear Receptors e.g. Retinoid Receptors, Ion Channels e.g. Calcium channel, Enzymes e.g. Cholinesterase, Receptors e.g. Adenosine Receptor in the present work different targets of drug action are discussed in brief which is an essential part during discovery phase of a drug.

Keywords


Drug Design, Drug Discovery, Receptors, Targets.

References