Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Management of Male Infertility by Neutraceutical: A Review


Affiliations
1 BM College of Pharmaceutical Education and Research, Indore (MP), India
2 Radharaman Institute of Pharmacy, Bhopal (M.P), India
3 Department of Pharmaceutics, Vels College of Pharmacy Chennai, (T.N), India
     

   Subscribe/Renew Journal


Seminal oxidative stress in the male reproductive tract is known to result in peroxidative damage of the sperm plasma membrane and loss of its DNA integrity. Normally, a balance exists between concentrations of reactive oxygen species (ROS) and antioxidant scavenging systems. One of the rational strategies to counteract the oxidative stress is to increase the scavenging capacity of seminal plasma. Numerous studies have evaluated the efficacy of antioxidants in male infertility. In this review, the results of different studies conducted have been analyzed, and the evidence available to date is provided. We outline the role of nutritional and biochemical factors from the nutraceutical of anti oxidant class like lycopenes, selenium, folate, zinc, glutathiones, l-arginine, l-carnitine, coenzyme-Q, Vitamin E,Vitamin C,Vitamin B12 in reproduction and male infertility problem.

Keywords

Nutraceutical, Male Infertility, SOS, ROS, Antioxidants.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Gupta NP ,Kumar R.Lycopene therapy in idiopathic male infertility a preliminary report.Int Urol Nephrol 2002;34(3):369-72.

  • Altman, Roberta, Michael J S. The Cancer Dictionary. New York: Facts on File, 1992.

  • http://www.pdrhealth.com/drug_info/drugprofiles/lycopene

  • Cook, Allan R. Alternative Medicine Sourcebook. Detroit: Omnigraphics, 1999.

  • Palan P,Naz R,Changes in various antioxidants levels in human seminal plasma related to immuno infertility.Arch Androl.1996 March-April;36(2):139-43.

  • Claire Cassidy,James S. Gordon, Ralph W. Moss, Richard Pavek. Allen The Alternative Medicine Sourcebook and Health Reference Series.

  • Shalini S,Bansal MP,Role of selenium in regulation of spermatogenesis; involvement of activator protein 1, Biofactors.2005;23(3):151-62.

  • Ebisch I M ,Thomas CM ,Peters WH, Braat DD, Steegers - Theunissen RP,The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update.2007.March-April;13(2):163-74.

  • New England Journal of Medicine. 342.5 (2000):326-333.

  • Woodham, Anne, and David Peters. Encyclopedia of Healing Therapies. New York: Dorling Mancini A, De Marinis L, Littaru GP, Balercia G, An update of Coenzyme Q10 implication in male infertility:biochemical and therapeutic aspects. Biofactors 2005;25(1-4):165-74.

  • "Dietary Supplement Health and Education Act of 1994."CIS: Lexis-Nexis. 17 Feb. 2000<http://web.lexis-nexis.com/congcom.

  • Morales ME ,Rico G, Bravo C, Tapia R, Alvarez C, Mendez JD, Progressive motality increase caused by l-argenine and polyamines in sperm from patients with idiopathic and diabetic asthenozoospermia,Ginecol Obstet Mex 2003 June ;71:297-303.

  • Wilk et al. v. the American Medical Association, Nos. 87-2672, 87-2777, U.S. Court of Appeals for the Seventh Circuit, 1990. Academic Universe: Lexis-Nexis.4 Mar. 2000,<http://web.lexisnexis. com/univers>

  • Whitney, Eleanor Noss, and Sharon Rady Rolfes. Understanding Nutrition. 4th ed. Belmont:Wadsworth, 1999.

  • Oshio S,Ozaki S,Ohkawa I, Tajima T,Kaneko S ,Mohri H, Mecobalamin promotes mouse sperm maturation , Andrologia 1989 March-April;21(2):167-73.

  • http://www.fertilitymemphis.com/article_improving_male_fertility.aspes

  • http:// humupd.oxfordjournals.org/cgi/reprint/13/2/163.pdf

  • http://www.bodyandfitness.com/Information/Menhealth/infertility.htm

  • http://medind.nic.in/iaf/t09/i3/iaft09i3p312.pdf(vit-c)

  • http://www.berkeley.edu/news/media/releases/2001/02/26_diet.html

  • http://www.fertilaid.com/l-carnitine-fertility.asp

  • http://www.maleinfertility.org/lifestyle.html

  • http://dx.doi.org/10.1111/j.14...07.06804.x

  • http://www.holisticonline.com/remedies/infertility/inf_men_nutrition.htm

  • http://www.VitaminLore.com

  • http://www.maleinfertility.org/lifestyle.html

  • Chinoy N. J, Structure and physiology of mammalian vas deferens in relation to fertility regulation, J. Biosci. March 1985;7(2):215-221.

  • Sharma J.D. Lalita Sharma and Yadav Poonam, Antifertility Efficacy of Piper betle Linn. (Petiole) on Female Albino Rats, Asian J. Exp. Sci., 2007; 21(1):145-150.

  • Piyali Das, A R Choudhari, A Dhawan and Ramji Singh, Role of ascorbic acid in human seminal plasma against the oxidative damage to the sperms, Indian Journal of Clinical Biochemistry,2009;24(3):312-315.

  • American Society of Andrology, Journal of Andrology. November/December 2005.26(6).

  • Goyal. A, Chopra M, Lwaleed B.A, Birch B and Cooper A.J. (2007) the effects of dietary lycopene supplementation on human seminal plasma.BJU International, 99; 6:1456-1460.

  • http://www.agresearch.umd.edu/CFNAP/Outreach/Conference%20Proceedings/pdfs/Tomato_Lycopene_Final_Web.pdf

  • http://www.vasdoctor.com

  • http://www.holisticonline.com/remedies/infertility/inf_men_nutrition.htm

  • Agarwal. A, Kiran P, Shyam S,R. Allamanenimer, M. Said, Reproductive BioMedicine Online, June 2004;8(6); 616-627(12).


Abstract Views: 326

PDF Views: 2




  • Management of Male Infertility by Neutraceutical: A Review

Abstract Views: 326  |  PDF Views: 2

Authors

S. C. Shivhare
BM College of Pharmaceutical Education and Research, Indore (MP), India
Arjun O. Patidar
BM College of Pharmaceutical Education and Research, Indore (MP), India
K. G. Malviya
Radharaman Institute of Pharmacy, Bhopal (M.P), India
K. Venkatesh
Department of Pharmaceutics, Vels College of Pharmacy Chennai, (T.N), India
Kuldeep Rathod
Department of Pharmaceutics, Vels College of Pharmacy Chennai, (T.N), India

Abstract


Seminal oxidative stress in the male reproductive tract is known to result in peroxidative damage of the sperm plasma membrane and loss of its DNA integrity. Normally, a balance exists between concentrations of reactive oxygen species (ROS) and antioxidant scavenging systems. One of the rational strategies to counteract the oxidative stress is to increase the scavenging capacity of seminal plasma. Numerous studies have evaluated the efficacy of antioxidants in male infertility. In this review, the results of different studies conducted have been analyzed, and the evidence available to date is provided. We outline the role of nutritional and biochemical factors from the nutraceutical of anti oxidant class like lycopenes, selenium, folate, zinc, glutathiones, l-arginine, l-carnitine, coenzyme-Q, Vitamin E,Vitamin C,Vitamin B12 in reproduction and male infertility problem.

Keywords


Nutraceutical, Male Infertility, SOS, ROS, Antioxidants.

References