Research Journal of Pharmacology and Pharmacodynamics

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A Comparative Randomized Study of Guggulu and Atorvastatin Hypercholesterolemia Patients


Affiliations
1 K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
2 P. Ramesh Babu Citi Cardiac Centre, Vijayawada-8., India
3 P. Ramesh Babu Citi Cardiac Centre,Vijayawada-8., India
     

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Obesity is an important health hazard a known risk factor for several diseases like coronary heart disease (CHD), angina pectoris hypertension, cardiac failure etc. Recent investigations and national cholesterol education program, adult treatment panel-III (NCEP, ATP-III) guidelines stating that the LDL-cholesterol is the primary target of treatment in clinical lipid management. In this manuscript to evaluate the safety and efficacy of Googol and Atorvastatin after excluding patients with exclusion criteria, thirty adult patients were allotted to study the medication. Randomly atorvastatin (20mg) was allotted to fifteen patients and guggulu (250mg) for fifteen patients for six weeks were allotted, before and after the treatment lipoprotein profile estimation was done. Weekly once checked for side effects. Out of thirty patients only twenty five were available for efficacy analysis (14 in guggulu group and 11 in atorvastatin group) the rest were dropouts. There is a satisfactory 7 significant reduction in LDL-cholesterol from the basic line value in atorvastatin group (29.5%) in comparison with guggul group (7%). HDL- cholesterol levels were raised in Atorvastatin group (4%) but there is no change in guggul group etc. By these results we can conclude that Atorvastatin is superior to guggul in lowering LDLcholesterol and raising HDL-cholesterol.

Keywords

Atorvastatin, Guggul, LDL-Cholesterol, HDL-Cholesterol, Triglycerides, Patients.
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  • A Comparative Randomized Study of Guggulu and Atorvastatin Hypercholesterolemia Patients

Abstract Views: 602  |  PDF Views: 8

Authors

Ch. Nagabhushanam
K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
P. Ramesh Babu
P. Ramesh Babu Citi Cardiac Centre, Vijayawada-8., India
N. K. Durga Devi
K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India
A. Vasu
P. Ramesh Babu Citi Cardiac Centre,Vijayawada-8., India
G. Devala Rao
K.V.S.R Siddhartha College of Pharmaceutical Sciences, Vijayawada-10, India

Abstract


Obesity is an important health hazard a known risk factor for several diseases like coronary heart disease (CHD), angina pectoris hypertension, cardiac failure etc. Recent investigations and national cholesterol education program, adult treatment panel-III (NCEP, ATP-III) guidelines stating that the LDL-cholesterol is the primary target of treatment in clinical lipid management. In this manuscript to evaluate the safety and efficacy of Googol and Atorvastatin after excluding patients with exclusion criteria, thirty adult patients were allotted to study the medication. Randomly atorvastatin (20mg) was allotted to fifteen patients and guggulu (250mg) for fifteen patients for six weeks were allotted, before and after the treatment lipoprotein profile estimation was done. Weekly once checked for side effects. Out of thirty patients only twenty five were available for efficacy analysis (14 in guggulu group and 11 in atorvastatin group) the rest were dropouts. There is a satisfactory 7 significant reduction in LDL-cholesterol from the basic line value in atorvastatin group (29.5%) in comparison with guggul group (7%). HDL- cholesterol levels were raised in Atorvastatin group (4%) but there is no change in guggul group etc. By these results we can conclude that Atorvastatin is superior to guggul in lowering LDLcholesterol and raising HDL-cholesterol.

Keywords


Atorvastatin, Guggul, LDL-Cholesterol, HDL-Cholesterol, Triglycerides, Patients.

References