Research Journal of Pharmacology and Pharmacodynamics

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Anticonvulsant Activity of Leaf Extracts of Anacardium occidentale. Linn


Affiliations
1 Department of Pharmacology, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, India
2 Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, Andhra Pradesh, India
3 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia – Serdang 43400, Selangor Darul Ehsan, Malaysia
4 Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad–500001, Andhra Pradesh, India
5 Bharat Institute of Technology, Ibrahimpatnam, RR. Dist., Hyderabad - 500001. Andhra Pradesh, India
     

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The aim of the present study was to investigate the anticonvulsant effect of methanolic and aqueous extracts of the leaves of Anacardium occidentale Linn. on electrically and chemically induced seizures. The methanolic and aqueous extracts of the leaves of A. occidentale (250 and 500 mg/kg.b.w. p.o.) were studied for the anticonvulsant effect on Maximum electroshock (MES) and Pentylene tetrazole (PTZ) induced convulsions in mice. The latency of onset of tonic-clonic convulsions and the number of animals protected from tonic convulsions were noted. AOMEE and AOAQE (500 mg/kg.b.w.p.o) significantly reduced the onset and duration of seizures induced by maximal electroshock (MES). The same dose also protected animals from pentylene tetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures.

Keywords

Anacardium occidentale, Anticonvulsant Activity, MES and PTZ Induced Convulsions.
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  • Sander JWAS, Shorvon SD. Epidemiology of epilepsies. J Neurol Neurosurg Psychiatry 1996; 61: 433-443.

  • Smith MC, Bleck TP. Convulsive Disorders: Toxicity of anticonvulsants, Clin Neuropharmacol, 1991; 14: 97-115

  • Mattson RH. Efficacy and adverse effects of established and new antiepileptic drugs, Epilepsia 1995; 36 (2): S13-S26.

  • SamrJn EB, Van Duijn CM , Koch S, Hiidesmaa VK, Klepel H, Bardy AH, Mannagetta GB, Deichl AW, Gaily E, Granstron ML, Meinardi AH, Grobbee DE, Hofman A, Janz D, Lindhout D. Maternal use of antiepileptic drugs and the risk of major congenital malformations : A joint European prospective study of human teratogenesis associated with material epilepsy. Epilepsia 1997; 38: 981.

  • Longuefosse, J.L. and E. Nossin, 1996. Medical ethnobotany survey in Martinique . J. Ethnopharmacol., 53:117-142.

  • Kamtchouing, P., S.D. Sokeng, F.P. Moundipa, P. Watcho, B.H. Jatsa and D. Lontsi,. Protective role of Anacardium occidentale extract against streptozotocin-induced diabetes in rats, J. Ethnopharmacol.,1998; 62: 95-99.

  • Harbone JB. Phytochemical methods. A Guide to Modern Techniques of Plant Analysis. 2nd Ed, Chapman and Hall, London, 1984; 84-274.

  • Khandelwal KR. Practical Pharmacognosy-Techniques and Experiments. Nirali Prakashan; 2002.

  • Turner RA: Anticonvulsants. In: Screening methods in Pharmacology. RA Turner Ed. Vol. I , New York and London: Academic Press, 1965,64-65.


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  • Anticonvulsant Activity of Leaf Extracts of Anacardium occidentale. Linn

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Authors

Syed Safiullah Ghori
Department of Pharmacology, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, India
Md. Shamim Qureshi
Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, Andhra Pradesh, India
Mohammed Safwan Ali Khan
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia – Serdang 43400, Selangor Darul Ehsan, Malaysia
Asma Khanam
Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad–500001, Andhra Pradesh, India
Jitendra Patel
Bharat Institute of Technology, Ibrahimpatnam, RR. Dist., Hyderabad - 500001. Andhra Pradesh, India

Abstract


The aim of the present study was to investigate the anticonvulsant effect of methanolic and aqueous extracts of the leaves of Anacardium occidentale Linn. on electrically and chemically induced seizures. The methanolic and aqueous extracts of the leaves of A. occidentale (250 and 500 mg/kg.b.w. p.o.) were studied for the anticonvulsant effect on Maximum electroshock (MES) and Pentylene tetrazole (PTZ) induced convulsions in mice. The latency of onset of tonic-clonic convulsions and the number of animals protected from tonic convulsions were noted. AOMEE and AOAQE (500 mg/kg.b.w.p.o) significantly reduced the onset and duration of seizures induced by maximal electroshock (MES). The same dose also protected animals from pentylene tetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures.

Keywords


Anacardium occidentale, Anticonvulsant Activity, MES and PTZ Induced Convulsions.

References