Research Journal of Pharmacology and Pharmacodynamics

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Hepatoprotective Activity of Aqueous and Alcoholic Extracts from Corm's of Amorphophallus paeonifolius against Carbontetra Chloride Induced Hepatotoxicity in Albino Rats


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1 Department of Pharmacy, Annamalai University, Annamalai Nagar TN, India
     

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In the present study, the pre-treatment of rats with Amorphophallus paeoniifolius. Alcoholic and aqueous extracts protected the animals against CCl4 induced hepatotoxicity. The treatment significantly reduced the serum GOT, GPT, ALP, oxidation of GSH, GST levels and liver weight. The hepatoprotective nature of aqueous and alcoholic extracts of this plant against CCl4 induced hepatic oxidative stress may be attributed to the presence of phenolic compounds. Further this was evidenced by free radical scavenging activity, reduced lipid peroxidation, reduced glutathione (GSH) radical scavenging activity and nitric oxide scavenging activity by both extracts of Amorphophallus paeonifolius. The present study reveals that Amorphophallus paeoniifolius possesses a hepatoprotective action.

Keywords

Amorphophallus Paeonifolius, Aqueous and Alcoholic Extracts, Hepatoprotective, Hepatotoxity.
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  • Hepatoprotective Activity of Aqueous and Alcoholic Extracts from Corm's of Amorphophallus paeonifolius against Carbontetra Chloride Induced Hepatotoxicity in Albino Rats

Abstract Views: 353  |  PDF Views: 2

Authors

K. Kathiresan
Department of Pharmacy, Annamalai University, Annamalai Nagar TN, India
S. Tom
Department of Pharmacy, Annamalai University, Annamalai Nagar TN, India
V. V. Venkatachalam
Department of Pharmacy, Annamalai University, Annamalai Nagar TN, India
H. Penchalaiah
Department of Pharmacy, Annamalai University, Annamalai Nagar TN, India

Abstract


In the present study, the pre-treatment of rats with Amorphophallus paeoniifolius. Alcoholic and aqueous extracts protected the animals against CCl4 induced hepatotoxicity. The treatment significantly reduced the serum GOT, GPT, ALP, oxidation of GSH, GST levels and liver weight. The hepatoprotective nature of aqueous and alcoholic extracts of this plant against CCl4 induced hepatic oxidative stress may be attributed to the presence of phenolic compounds. Further this was evidenced by free radical scavenging activity, reduced lipid peroxidation, reduced glutathione (GSH) radical scavenging activity and nitric oxide scavenging activity by both extracts of Amorphophallus paeonifolius. The present study reveals that Amorphophallus paeoniifolius possesses a hepatoprotective action.

Keywords


Amorphophallus Paeonifolius, Aqueous and Alcoholic Extracts, Hepatoprotective, Hepatotoxity.

References