Research Journal of Pharmacology and Pharmacodynamics

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Hepatoprotective Effect of Pergularia daemia on Cadmium Chloride Induced Toxicity in Rats


Affiliations
1 Department of Biotechnology, J.J college of Arts and Science, Pudukottai, India
2 School of Life Sciences, Department of Biotechnology, University College of Engineering, JNTU, Kakinada, Andhra Pradesh, India
3 Department of Biotechnology, Bharathidasan University, Trichy, India
     

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The present study was undertaken to examine the inhibitory effect of the Pergularia daemia on cadmium chloride induced hepatoprotective activity in liver. In rats injected with cadmium chloride, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), γ-glutamyl transferase (GGT) was significantly (p < 0.05) increased when compared to those values in control rats. The rats administrated with P. daemia extract and cadmium chloride showed a significantly (p < 0.05) decreased levels of serum AST, ALP, LDH and GGT. This study suggested that P. daemia may be implicated as a hepatoprotective agent for therapeutic purposes.

Keywords

Cadmium Chloride, Hepatoprotective Activity, Pergularia daemia.
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  • Tephyly TR et al. The effects of metals on hem biosynthesis and metabolism. Fed Toxicol Sci. 1978; 26: 337- 358.

  • Deur CD, Stone MD, Frenkel EP. Trace metals in hematopoiesis. Am J Hemato. 1981; 11: 309-331.

  • Wong KL, Klaassen CD. 1982. Neurotoxic effects of cadmium in young rats. Toxicol Applied Pharmacol, 1982; 63: 330-337.

  • Noedberg GF, Kjellstorm T, Nordberg GE. Cadmium and helath in: A Toxicological and epidemiological appraisal, Vol. 1, edited by Friberg L, Elinder CG, Kjellstrom T, Nordberg GF (CRC Press, Boca Raton, USA) 1985; 168.

  • Sathish CJ et al. Ethnopharmacological evaluation of P. daemia (Forsk.) Chivo. Phytother Res. 1998; 12: 378-380.

  • Anjaneyulu ASN, Raju DVSN, Srinivasa Rao S. Chemical evaluation of P. daemia. Indian J Chem. 1998; 37B: 318-320.

  • Mittal OP, Tammz C, Reichstein T. Glycosides and aglycons. CCXXVII. The glycosides of Pergularia extensa. Helv Chim Acta. 1962; 45: 907.

  • Kakrani HKN, Saluja AK. Traditional treatment through gerbs in Kutch district, Gujarat state, India. Part II. Analgesic, anti-inflammatory, antirheumatic, antiarthritic plants. Fitoterapia. 1994; 65 (5): 427-430.

  • De laszlo H, Henshaw PS. Plant materials used by primitive peoples to affect fertility. Science. 1954; 119: 626-631.

  • Elango V et al. Pharmacological and microbiological studies on Pergularia extensa. Fitoterapia. 1985; 56 (5): 300-302.

  • Reitman S, Frankel S. A colorimetric method for the determination of serum oxaloacetic and glytamic pyruvate transaminase. Am J Clin Pathol.1957; 28:56-63.

  • King J. The hydrolyases-acid and alkaline phosphates. In: Practical clinical Enzymology, Van D (ed.), No strand Co Ltd, London.1965; 191-108.

  • Rosalki and Rao. Serum gamma-glutamyl transpeptidase activity in alcoholism. Clin Chim Acta.1972; 39: 41-47.

  • Duncan BD. Multiple range tests for correlated and heteroscedastic means. Biometrics. 1957; 13: 359-364.

  • Jarup L et al. Low level exposure to cadmium and early kidney damage: The OSCAR study Occup Environ Med.2000; 57: 668-672.

  • Rikans LE, Yamano T. Mechanisms of cadmium-mediated acute hepatotoxicity. J Biochem. 2000; 14: 110-117.

  • Tzirogiannis KN et al. Time-course of cadmium-induced acute hepatotoxicity in the rat liver: The role of apoptosis. Arch Toxicol. 2003; 77: 694-701.

  • Kalapose MP, Littauer A, Gischolar_main H. Has reactive oxygen a role in methylglyoxal toxicity.A study on cultured rat hepatocyte. Arch Toxicol. 1993; 67: 369-372.


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  • Hepatoprotective Effect of Pergularia daemia on Cadmium Chloride Induced Toxicity in Rats

Abstract Views: 242  |  PDF Views: 2

Authors

P. Vinoth Kumar
Department of Biotechnology, J.J college of Arts and Science, Pudukottai, India
Ch. Sudheer Kumar
School of Life Sciences, Department of Biotechnology, University College of Engineering, JNTU, Kakinada, Andhra Pradesh, India
V. Veera Thamarai Selvi
Department of Biotechnology, J.J college of Arts and Science, Pudukottai, India
A. Amala Bricey
Department of Biotechnology, Bharathidasan University, Trichy, India

Abstract


The present study was undertaken to examine the inhibitory effect of the Pergularia daemia on cadmium chloride induced hepatoprotective activity in liver. In rats injected with cadmium chloride, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), γ-glutamyl transferase (GGT) was significantly (p < 0.05) increased when compared to those values in control rats. The rats administrated with P. daemia extract and cadmium chloride showed a significantly (p < 0.05) decreased levels of serum AST, ALP, LDH and GGT. This study suggested that P. daemia may be implicated as a hepatoprotective agent for therapeutic purposes.

Keywords


Cadmium Chloride, Hepatoprotective Activity, Pergularia daemia.

References