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Antidiabetic Activity of Swietenia mahagoni Seed Powder in Alloxan Induced Diabetic Mice


Affiliations
1 Department of Pharmacology, Ultra College of Pharmacy, Madurai, India
2 Department of Pharmaceutical Biotechnology, Ultra College of Pharmacy, Madurai, India
3 Department of Pharmacology, Madurai Medical College, Madurai, India
     

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Swietenia mahagoni (Meliaceae) is an evergreen hard wood timber species widely distributed in India and has ethno medicinal uses in malaria, diabetes, anemia, diarrhoea, fever, and dysentery. In this present study antidiabetic effect of Swietenia mahagoni seeds were evaluated in alloxan induced diabetic mice. Blood and urine Glucose levels, food and water consumptions and histopathological studies were determined. In diabetic mice, Swietenia mahagoni seeds significantly reduced the elevated blood glucose level by 43.92% at 500mg/kg and 42.47% at 250mg/kg compared to vehicle treated diabetic mice, without increase in urine glucose, food and water intake. The experimental data indicated that Swietenia mahagoni demonstrated significant antidiabetic action in alloxan induced diabetic mice and could be a potential orally active drug for diabetes mellitus.

Keywords

Antidiabetic, Indian Mahogany, Alloxan, Diabetic Mice, Swietenia.
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  • Antidiabetic Activity of Swietenia mahagoni Seed Powder in Alloxan Induced Diabetic Mice

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Authors

R. Sathish
Department of Pharmacology, Ultra College of Pharmacy, Madurai, India
K. Natarajan
Department of Pharmaceutical Biotechnology, Ultra College of Pharmacy, Madurai, India
S. Selvakumar
Department of Pharmacology, Madurai Medical College, Madurai, India

Abstract


Swietenia mahagoni (Meliaceae) is an evergreen hard wood timber species widely distributed in India and has ethno medicinal uses in malaria, diabetes, anemia, diarrhoea, fever, and dysentery. In this present study antidiabetic effect of Swietenia mahagoni seeds were evaluated in alloxan induced diabetic mice. Blood and urine Glucose levels, food and water consumptions and histopathological studies were determined. In diabetic mice, Swietenia mahagoni seeds significantly reduced the elevated blood glucose level by 43.92% at 500mg/kg and 42.47% at 250mg/kg compared to vehicle treated diabetic mice, without increase in urine glucose, food and water intake. The experimental data indicated that Swietenia mahagoni demonstrated significant antidiabetic action in alloxan induced diabetic mice and could be a potential orally active drug for diabetes mellitus.

Keywords


Antidiabetic, Indian Mahogany, Alloxan, Diabetic Mice, Swietenia.

References