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Alpha-Glucosidase Inhibitory Activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb Bark Extract
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Alpha glucosidase inhibitory activities of Wrightia tinctoria Roxb and Schrebera swietenoides Roxb ethanol extracts were investigated individually. Wrightia tinctoria Roxb and Schrebera swietenoides Roxb bark extract showed in-vitro inhibitory activity of intestinal alpha glucosidase enzyme maltase. Analysis of data confirms that alpha glucosidase inhibition activity was the maximum at 1500mcg/ml of Wrightia tinctoria Roxb bark and 2000mcg/ml of Schrebera swietenoides Roxb bark. The purpose of study was to know whether Wrightia tinctoria Roxb bark and Schrebera swietenoides Roxb bark extract could reduce intestinal absorption of monosaccharides by inhibiting disaccharide hydrolysis. These results suggest that the Wrightia tinctoria Roxb bark extract and Schrebera swietenoides Roxb bark has little potent alpha glucosidase inhibitory activity individually and would be effective in suppression of elevation in blood glucose.
Keywords
Wrightia tinctoria Roxb, Schrebera swietenoides Roxb, Maltase, Acarbose.
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- Puls, W., U. Keup, H. P. Krause et al., Glucosidase Inhibition. A new approach to the treatment of diabetes, obesity, and hyperlipoproteinaemia. Naturwissen-schaften, 1977, 64: 536 537.
- Ratner, L. Glucosidase inhibitors for treatment of HIV-1 infection. AIDS Res. Hum. Retroviruses, 1992, 8(2): 165-173.
- Nisioka,T., Watanabe.J.,Kawabata, J.,and Niki,R., Isolation and activity of N-coumaroyl tyramine an glucosidase inhibitor in welsh onion (Allium Fistulosum). Biosci. Biotechnol. Biochem, 1997, 61 ,1138-1141.
- Toda,H.,Kawabata,J.,andKasuariT., Alpha-glucosidase Inhibitors From Clove(Syzgium Armactum). Biosci.Biotechnol.Biochem, 2000, 64, 294-298.
- Honda, M and Hara,V., Inhibition of rat small intestinal sucrase and glucosidase activities by tea polyphenols. Biosci. Biotechnol. Biochem, 1993, 57,123-124.
- Del Prato, S. Post-prandial hyperglycaemia-the necessity for better control,Int J Clin Pract Suppl. 2000, 112, 3S-8S.
- Nadkarni K. M. Indian Materia Medica, Vol.I (Bombay: Popular Prakashan), 1976, 1296.
- C. P. Khare, Indian Medicinal Plants- An illustrated dictionary, spinger publications, pg.589.
- Yuste, P.; Longstaff, M.; McCorquodale, C. The effect of proanthocyanidin-rich hulls and proanthocyanidin extracts from bean (Vicia faba L.) hulls on nutrient digestibility and digestive enzyme activities in young chicks. Br. J. Nutr. 1992, 67, 57-65.
- Longstaff, M.; McNab, J.M. The inhibitory effects of hull polysaccharides and tannins of field beans (Vicia faba L.) on the digestion of amino acids, starch and lipid and on digestive enzyme activities in young chicks. Br. J. Nutr. 1991, 65, 199-216.
- Kuk.-Kook Lee, J.-J.Cho, J. Park and J. D. Choi Anti-elastase and anti-hyaluronidase of phenolic substance from Areca catechu as a new anti-ageing agent. International Journal of Cosmetic Science. 2001, 23(6): 341-346.
- Kobayashi, Y.; Suzuki, M.; Hideo, S.; Arai, S.; Yukihiko, H.;Suzuki, K.; Miyamoto, Y.; Shimizu, M. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. J. Agric. Food Chem 2000, 48:5618-5623.
- Loomis, W. D. and J. Battaile.. Plant phenolics and the isolation of plant enzymes. Phytochemistry, 1966, 5:423.
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