Research Journal of Pharmacology and Pharmacodynamics

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Renal Protectant Activity of Cochlearia armoracia in 5/6-Nephrectomized Rat Model


Affiliations
1 Department of Pharmacology, J.S.S. College of Pharmacy, Rocklands, Ooty-643001, India
2 Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India
     

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We investigated the effect of aqueous and ethanolic extract of Cochlearia armoracia at a dose of 200 and 400 mg/kg in 5/6 nephrectomized rats for its nephroprotective activity. Blood samples were collected for the measurement of serum creatinine, urea, blood urea nitrogen, uric acid. Urine samples were collected for the measurement of urine volume, sodium and potassium excretion levels. In nepherctomized rat the blood parameters were significantly increased and urine parameters were significantly altered to disease condition. Both the extracts at a dose level of 400 mg/kg showed significant (p<0.01) decrease in serum creatinine, urea, blood urea nitrogen, uric acid and increases urinary volume and sodium and potassium excretions. The present study revealed that the oral administration of aqueous and ethanolic extracts at 400 mg/kg dose exhibit a significant nephroprotective activity in 5/6 nephrectomized rat model.

Keywords

Cochlearia armoracia, Nephrectomized and Nephroprotective.
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  • Grieve M. A Modern Herbal. Dover Publication Inc, New York. 1995.

  • Bown D. Encyclopedia of herbs and their uses. DK Publishing Inc, New York. 1996.

  • Hansen L. Content of glucosinolates in Horseradish (Armoracia Rusticana). Tidsskr Planteavl. 1974; 73: 408-410.

  • Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. Council of Scientific and Industrial Research, New Delhi. 1992.

  • Goldberg A, Busse WR, Bluementhal M. A therapeutic guide to herbals: The commission E Monographs. Boston, 1998.

  • Podjarny E, Hasdan G, Bernheim J, Rashid G, Green J, Korzets Z et al. Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats. Nephrol Dial Transplant. 2004; 19: 2223-27.

  • Braunlich H, Marx F, Fleck C, Stein G. Kidney function in rats after 5/6 nephrectomy (5/6 NX): effort of treatment with vitamin E. Exp Toxicol Pathol. 1997; 12: 135-139.

  • Afzal M, Iqbal A, Inamuddin M. Diuretic and nephroprotective effect of Jawarish Zarooni Sada-a polyherbal unani formulation. J Ethnopharmacol. 2004; 91: 219-223.

  • Ganapathy S, Dash GK, Subburaju T, Suresh P. Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts. Fitoterapia 2002; 73: 28-31.

  • Englert J, Harmish Feger G. Diuretic action of aqueous Orthosiphon extract in rats. Planta Medica. 1992; 58; 237-238.


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  • Renal Protectant Activity of Cochlearia armoracia in 5/6-Nephrectomized Rat Model

Abstract Views: 327  |  PDF Views: 4

Authors

A. Shanish Antony
Department of Pharmacology, J.S.S. College of Pharmacy, Rocklands, Ooty-643001, India
K. Jayasankar
Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India
Partha Deb Roy
Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India
N. Pankaj
Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India
P. Dhamodaran
Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India
B. Duraiswamy
Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India
K. Elango
Department of Pharmacology, JSS College of Pharmacy, Ooty-643001, Tamilnadu, India

Abstract


We investigated the effect of aqueous and ethanolic extract of Cochlearia armoracia at a dose of 200 and 400 mg/kg in 5/6 nephrectomized rats for its nephroprotective activity. Blood samples were collected for the measurement of serum creatinine, urea, blood urea nitrogen, uric acid. Urine samples were collected for the measurement of urine volume, sodium and potassium excretion levels. In nepherctomized rat the blood parameters were significantly increased and urine parameters were significantly altered to disease condition. Both the extracts at a dose level of 400 mg/kg showed significant (p<0.01) decrease in serum creatinine, urea, blood urea nitrogen, uric acid and increases urinary volume and sodium and potassium excretions. The present study revealed that the oral administration of aqueous and ethanolic extracts at 400 mg/kg dose exhibit a significant nephroprotective activity in 5/6 nephrectomized rat model.

Keywords


Cochlearia armoracia, Nephrectomized and Nephroprotective.

References