Research Journal of Pharmacology and Pharmacodynamics

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Neuropharmacological Profile of Aqueous and Ethanolic Extract of Pithecellobium dulce Benth Leaves in Mice


Affiliations
1 Department of Pharmacology, Tatyasaheb Kore College of Pharmacy, A/P: Warananagar - 416113, Tal: Panhala, Dist: Kolhapur, Maharashtra, India
2 Tatyasaheb Kore College of Pharmacy, Warananagar - 416113, Maharashtra, India
     

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The present study was undertaken to evaluate several neuropharmacological activities of the aqueous and ethanolic extracts of Pithecellobium dulce Benth (Leguminosae) leaves in swiss albino mice. A crude extracts were given orally and its effects were tested on spontaneous motor activity, motor coordination, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced convulsions. The leaves of plant were extracted with water and ethanol by maceration and soxhelation respectively. Preliminary phytochemical screening of both extracts was carried out to determine the nature of phytoconstituents present in it. Acute toxicity studies of the both extracts were performed using mice and dose of 200 mg/kg was selected for further studies. Results from experimental models showed prominent decrease in locomotor activity and motor coordination for both extracts. In sodium pentobarbital-induced hypnosis both extracts exhibited significant hypnotic effect. Results of anticonvulsant activity testing by PTZ method revealed that aqueous and ethanolic extract of Pithecellobium dulce could not decreased the convulsions as well as mortality in mice. In conclusion, this study demonstrates that an acutely administered single dose of an aqueous and ethanolic extracts of Pithecellobium dulce leaves possess skeletal muscle relaxation activity and can exert depressant effects on the CNS but no anticonvulsant action.

Keywords

Pithecellobium dulce, Neuropharmacology, Depressant, Hypnotic.
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  • Neuropharmacological Profile of Aqueous and Ethanolic Extract of Pithecellobium dulce Benth Leaves in Mice

Abstract Views: 267  |  PDF Views: 2

Authors

V. S. Mule
Department of Pharmacology, Tatyasaheb Kore College of Pharmacy, A/P: Warananagar - 416113, Tal: Panhala, Dist: Kolhapur, Maharashtra, India
V. H. Potdar
Tatyasaheb Kore College of Pharmacy, Warananagar - 416113, Maharashtra, India
S. D. Jadhav
Tatyasaheb Kore College of Pharmacy, Warananagar - 416113, Maharashtra, India
J. I. Disouza
Tatyasaheb Kore College of Pharmacy, Warananagar - 416113, Maharashtra, India

Abstract


The present study was undertaken to evaluate several neuropharmacological activities of the aqueous and ethanolic extracts of Pithecellobium dulce Benth (Leguminosae) leaves in swiss albino mice. A crude extracts were given orally and its effects were tested on spontaneous motor activity, motor coordination, sodium pentobarbital-induced hypnosis and pentylenetetrazole (PTZ)-induced convulsions. The leaves of plant were extracted with water and ethanol by maceration and soxhelation respectively. Preliminary phytochemical screening of both extracts was carried out to determine the nature of phytoconstituents present in it. Acute toxicity studies of the both extracts were performed using mice and dose of 200 mg/kg was selected for further studies. Results from experimental models showed prominent decrease in locomotor activity and motor coordination for both extracts. In sodium pentobarbital-induced hypnosis both extracts exhibited significant hypnotic effect. Results of anticonvulsant activity testing by PTZ method revealed that aqueous and ethanolic extract of Pithecellobium dulce could not decreased the convulsions as well as mortality in mice. In conclusion, this study demonstrates that an acutely administered single dose of an aqueous and ethanolic extracts of Pithecellobium dulce leaves possess skeletal muscle relaxation activity and can exert depressant effects on the CNS but no anticonvulsant action.

Keywords


Pithecellobium dulce, Neuropharmacology, Depressant, Hypnotic.

References